CLS 306 (BB) - Lecture 12: Rh Immune Globulin

anti-D Ab

Rh Immune Globiuline (RhIG) is a pharmaceutical drug that contains…

• Rh negative mothers negative for allo anti-D

• Potentially exposed to Rh+ RBCs

Rh Immune Globilin is given to mothers who are…

Intramusculare injection of 1 mL syringe

Administration of Rh Immune Globulin

• After abortion

• Miscarriage

• Termination of ectopic pregnancy

Micro Dose RhIG indications (3)

12 weeks gestation (antepartum)

Micro dose RhIG administration

50µg of anti-D for 2.5 mL Rh+ RBCs or 5 mL Rh+ WBCs

Micro dose RhIG volume

• After amniocentesis/cordocentesis

• Abdominal trauma during pregnancy

• Antepartum hemorrhage

• Postpartum

Full dose RhIG indications (4)

• Following abortion or miscarriage 12 weeks gestation

• ≥28 weeks gestation (antepartum)

• Within 72 hours postpartum (Rh+ or unknown fetus with no anti-D in mother)

Full dose RhIG administration (3)

300µL of anti-D for 15mL of Rh+ RBCs or 30 mL Rh+ WBCs

Full dose RhIG volume

weak AHG reaction for anti-D (passive anti-D)

If a mother has received an antepartum injection of RhIG. (——) can be expected in the ABS

Fetal cell volume from KB / 30 = # syringes given

• (NOTE: always add 1 to calculation)

Calculation for how much RhIG to give

IV Rh Immune Globulin (WinRho)

Therapy of choice for an Rh(-) patient accidentally infused with Rh(+) blood (>30mL)

Immune Thrombocytopenia Purpura (ITP)

Blood disorder characterized by low platelet, resulting in petechiae; treated with IV Rh Immune Globulin, which elevates platelet count

• Patient must be Rh positive

• Not effective after splenectomy

Requirements of ITP patient to be treated with anti-D immune globulin