7 - NSAIDS, ACETAMINOPHEN, DMARDS & DRUGS USED IN GOUT 2025

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12 Terms

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Selectively inhibits COX-3

MOA of Paracetamol

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Oxidation to cytotoxic intermediate called N-acetyl-p-benzoquinoneimine (NAPQI) by phase I cytochrome P450 enzymes (CYP2E1)

Mechanism of Paracetamol overdose

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Indomethacin

NSAID commonly used for closure of PDA

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Increased risk of coronary thrombosis and stroke

FDA warning for COX-2 inhibitors

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Certolizumab, Etanercept, Golimumab, Adalimumab, Infliximab

“I’m ThaNkFul to Sir Ethan. May Limo na, may netFlix pa.”

TNF-alpha inhibitors

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Hepatotoxicity, Mucosal ulcers, Hepatotoxicity, Hypersensitivity, Interstitial pneumonitis

Adverse effects of Methotrexate

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Mycophenolate mofetil

Least toxic immunomodulator for

SLE nephritis

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Inflammatory bowel disease

Rheumatoid arthritis

JRA

Ankylosing spondylitis

Uses of Sulfasalazine

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Probenecid, Lesinurad

Uricosuric agents

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Febuxostat

Reversible inhibitor of xanthine oxidase

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Allopurinol

Irreversible inhibitor of xanthine oxidase

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Increased risk of cardiovascular death and all-cause mortality

Blackbox warning for Febuxostat