7 - NSAIDS, ACETAMINOPHEN, DMARDS & DRUGS USED IN GOUT 2025
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12 Terms
Selectively inhibits COX-3
MOA of Paracetamol
Oxidation to cytotoxic intermediate called N-acetyl-p-benzoquinoneimine (NAPQI) by phase I cytochrome P450 enzymes (CYP2E1)
Mechanism of Paracetamol overdose
Indomethacin
NSAID commonly used for closure of PDA
Increased risk of coronary thrombosis and stroke
FDA warning for COX-2 inhibitors
Certolizumab, Etanercept, Golimumab, Adalimumab, Infliximab
“I’m ThaNkFul to Sir Ethan. May Limo na, may netFlix pa.”
TNF-alpha inhibitors
Hepatotoxicity, Mucosal ulcers, Hepatotoxicity, Hypersensitivity, Interstitial pneumonitis
Adverse effects of Methotrexate
Mycophenolate mofetil
Least toxic immunomodulator for
SLE nephritis
Inflammatory bowel disease
Rheumatoid arthritis
JRA
Ankylosing spondylitis
Uses of Sulfasalazine
Probenecid, Lesinurad
Uricosuric agents
Febuxostat
Reversible inhibitor of xanthine oxidase
Allopurinol
Irreversible inhibitor of xanthine oxidase
Increased risk of cardiovascular death and all-cause mortality
Blackbox warning for Febuxostat
Note 
Flashcards (117)