Cephalosporins

Flashcards about Cephalosporins and their anti-bacterial activity

What are some examples of 1st generation Cephalosporins?

Cefadroxil, cefazolin, cephalexin, cephalothin, cephapirin, cephradine

What is the anti-bacterial activity of 1st generation Cephalosporins?

Gram-positive cocci (pneumococci, streptococci, staphylococci), Proteus mirabilis, Escherichia coli, and Klebsiella pneumoniae

What are some examples of 2nd generation Cephalosporins?

Cefaclor, cefamandole, cefonicid, cefuroxime, cefprozil, loracarbef, ceforanide, cefoxitin, cefmetazole, cefotetan

What is the anti-bacterial activity of 2nd generation Cephalosporins?

Gram-positive cocci, Proteus, E. coli, Klebsiella species, Enterobacter, Serratia, some anaerobes, and Haemophilus influenzae

What are some examples of 3rd generation Cephalosporins?

Cefoperazone, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone, cefixime, cefpodoxime proxetil, cefditoren pivoxil, ceftibuten, moxalactam

What is the anti-bacterial activity of 3rd generation Cephalosporins?

Gram-negative bacteria (Serratia, Pseudomonas, Enterobacter, H. influenzae, Neisseria)

What is an example of a 4th generation Cephalosporin?

Cefepime

What is the anti-bacterial activity of 4th generation Cephalosporins?

Gram-negative bacteria (Serratia, Pseudomonas, Enterobacter, H. influenzae, Neisseria)
Gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae)

What is an example of a 5th generation Cephalosporin?

Ceftaroline

What is the anti-bacterial activity of 5th generation Cephalosporins?

Gram-positive bacteria (Streptococcus, S. aureus [MSSA and MRSA])
Gram-negative bacteria (E. coli, Klebsiella, H. Influenzae)