Canonical HIF regulation
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Last updated 2:36 PM on 1/8/26
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6 Terms
1
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What happens to HIF-alpha in high oxygen
It is continuously degraded
2
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What modification allows VHL binding
Proline hydroxylation
3
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What is VHL
An E3 ubiquitin ligase
4
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What happens to HIF-alpha in hypoxia
PHD activity is inhibited
5
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What happens after HIF dimerisation in hypoxia
The complex enters the nucleus and activates transcription
6
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What does HIF activation lead to
Expression of hypoxia-responsive genes
Note 
Flashcards (20)