Gastric secretion

what is the major area in the stomach used for food storage

fundus

what is the major area of exocrine secretions

body

what is the major area of endocrine secretion

pyloric antrum

what two main types of cells are found in the pyloric glands

G cells, D cells

what do G cells secrete

gastrin

what do D cells secrete

somatostatin

what are the three main types of cells found in the gastric glands

parietal cells, chief cells, enterochromaffin cells

what do parietal cells secrete

HCl

what do chief cells secrete

pepsinogen

what do enterochromaffin cells secrete

histamine

what are the three things that compose gastric secretions

HCl, pepsin, intrinsic factor

what is the intrinsic factor important for

absorption of vitamin B12

what pump works in the parietal cells to create alkaline tide

HCO3-/Cl-

what is an example of a PPI

omeprazole

what does PPI stand for

proton pump inhibitor

what is needed to activate pepsinogen and proteolyse it to pepsin

HCl

what cells secrete intrinsic factor

parietal cells

what condition do you have when you have a lack of intrinsic factor

pernicious anaemia

what are the three stages of gastric secretion

cephalic, gastric, intestinal

how does the stomach protect itself from self-digestion

gastric mucosa

why does the gastric mucosa become alkaline

alkaline tide

in what conditions is the gastric mucosal barrier breached

excessive use of NSAID, gastritis, ulcers