theme 3

hematocrit

% if blood occupied by rbc

erythropoiesis

-formation of rbc

-proerythroblast - erythroblast - reticulocyte (jumps into blood stream (1-2 days)) - erthrocyte

-need folate, b12, iron

hemolysis

• globin

• heme

  • fe3+

    • stored in lover by ferretin

      • later brought to bone marrow by transferrin for erythropoiesis

  • biliverdin

    • bilirubin

      • urobilinogen

        • urobilin

        • stercobiliin

• destruction of rbc

inflammatory response

1. increased vascular diameter (slower blood flow)

2. increase in vascular permeability

3. endothelial cells are activated (promote binding)

4. clotting (cytokines and chemotaxis)

5. protective response

hemostasis 

-stops bleeding

-primary

1. vascular phase: vasoconstriction

2. platelet phase: platelet plug formation

fibrinolysis

-dissolution of clot

plasmin hydrolyses fibrin strands and dissolves the clot