Immunology Mod 1

Immunology

Defined as resistance to disease.

Immunity

The state of being able to resist a particular disease especially through preventing the development of a pathogenic microorganism or by counteracting the effects of its products Function of the immune system is to recognize self from non-self and defend the body against non-self

Serum

Latin sero

Serology

The branch of science dealing with the measurement and characterization of antibodies, antigens, and other immunological substances in body fluids or serum.

430bc

Thucydides recorded during the plague in Athens that individuals who had previously contracted the disease recovered, and he recognized their immune status

1500AD

Chinese practiced a form of immunization by inhalation of crusts of smallpox lesions

1718

Practice of variolation (injection of materials from smallpox blisters) in Eastern Medicine and later into Western Medicine by Lady Montagnu

Jenner (1798)

Smallpox vaccination

Haeckel (1862)

Phagocytosis

Pasteur (1880-1881)

Live, attenuated chicken cholera and anthrax vaccines

Metchnikoff (1883-1905)Therapeutic vaccination. First report of live attenuated vaccine for rabies

Cellular theory of immunity through phagocytosis

Pasteur (1885)

Therapeutic vaccination. First report of live attenuated vaccine for rabies

Von Behring, Kitasara (1890)

Humoral theory of immunity proposed

Robert Koch (1881)

Demonstration of cutaneous (delayed-type) hypersensitivity

Paul Ehrlich (1900)

Antibody formation theory

Porter, Richet (1902)

Immediate-hypersensitivity anaphylaxis

Arthus (1903)

Arthus reaction of intermediate hypersensitivity

John Marrack (1938)Development of Polio Vaccine

Hypothesis of antigen-antibody binding

Salk, Sabin (1949)

Development of Polio Vaccine

Reed (1951)

Vaccine against yellow fever

Burnet (1957)

Clonal selection theory

Isaacs & Lindemann (1957)

Interferon

Davis (1964-1968)

T-cell and B-cell cooperation in immune response

Kohler (1957)

First monoclonal antibodies

Leroy Hood (1985-1987)

Identification of genes for T cell receptor

Mosmann (1086)

Th1 versus Th2 model of T helper cell function

Drazer (2005)

Development of human papillomavirus vaccine