Chromatin & Dynamics

DNA is stored in the ( )

nucleus

the ( ) is the site of ribosome synthesis

nucelolus

DNA is arranged into ( )

chromosomes

( ) is a structure of nucleic acids and proteins found in the nucleus of eukaryotic cells, carrying genetic information in the form of genes, which are arranged in a linear arrangement

chromosome

( )= DNA, histones and other proteins that bind to DNA

chromatin 

some of genome is euchromatin, ( )

un-packed/decondensed, transcription active form

euchromatin is transcriptionally ( ) form

active

some of genome is heterochromatin, meaning

packed/condensed, transcriptionally inactive form of chromatin

Heterochromatin include ( ) and ( ) next to ( )

centromeres

regions (called sub-telomeres)

telomeres

heterochromatin often consists of ( ) or ( )

highly repetitive sequences

tandem repeats

what are tandem repeats

blocks of 150-80 base pairs (bp) of DNA repeated over and over

in heterochromatin there is another type of repeat called ( ).

dispersed

( ) are the basic unit of chromatin

nucleosomes

look at pg 8

okay

Chromatin DNA can be bound to both ( ) and ( ) , the more ( ) it is, the ( ) for non-histone proteins to bind

histone proteins 

non-histone proteins 

unpacked

easier

The nucleosome ( ) is comprised of a ( )

basic unit of chromatin

8 histones

(8 polypeptides- 2 each of H2A,H2B,H3, and H4) and DNA

look at pg 10

ok

Nucleosomes fold to form the ( ), ( ) protrude from nucleosomes

30 nm chromatin fiber

histone tails

The 30 nm fiber fold into higher ( )

order structure

look at pg 13-15 and 18

okayc

chromosomes are ( ) structures

dynamic