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Nutrient
chemicals used by the body to produce energy. Provides building blocks, or sometimes it is something needed for tissue growth, repair, or maintained.
Major nutrient
carbs, proteins, lipids, and water. vitamins and minerals needed in smaller amounts.
Essential nutrients
something that has to be in the diet that we do not synthesize ourselves, some fatty acids are essential, vitamins, a few types of carbs, etc. around 50 needed things.
Glycogenesis
creation of glycogen, takes glucose and puts it in the storage form
Glycogenolysis
breaking down glycogen to release glucose.
Gluconeogenesis
creating glucose from non-carb sources. Create energy from fatty acids, glycerol, and even amino acids.
Carbohydrates
most come from plants except lactose
Monosaccharides
single sugar, glucose, fructose, galactose
Disaccharides
two sugar, sucrose, maltose, lactose, can be converted to glucose
Polysaccharides
complex sugars, starches, glycogen, cellulose, can be converted to glucose
Triglycerides
energy lipid that is 95% of lipids, can be stored. From sat and unsaturated
Saturated fats
from meat fats, whole milk, and cheese
Unsaturated fats
olive and peanut oils
Cholesterol
steroid found in the liver, egg yolks but not found in plants. Ingested or made in the body. Used for plasma membranes, bile salts, and steroids.
Phospholipids
major component of plasma membranes, used for plasma membranes, myelin sheaths, and bile
Linoleic acids
essential fatty acids, found in seeds, nuts, legumes, grains, and green leaves.
Lipids function
triglycerides make ATP, excess can be in adipose tissue and liver.
Eicosanoids
derived from fatty acids, used in inflammation, blood clotting, tissue repair, smooth muscle contraction.
Protein functions
chains of amino acids, protection for antibodies, regulation of enzymes and hormones, structure of collagen, muscle contraction with actin and myosin, and transportation of hemoglobin or ion channels.
Essential proteins
must be from diet
Nonessential proteins
body can synthesize these proteins
Complete proteins
contains all necessary amino acids from fish, chicken, eggs, cheese, meat.
Vitamins
most function as coenzyme, organic molecules in minute quantities in food.
Coenzyme
must be combined with another enzyme to work
Provitamins
can be converted into functioning vitamin.
Lipid soluble
can be stored in fatty tissues to the point of toxicity, vitamin A,d, e,k
Water soluble
remains for a short time but then are secreted, vitamin b, c and all others.
Antioxidants
metabolic byproduct that is short an electron or two, and leaves the cells damaged. Prevents formation of free radicals
Minerals
inorganic chemicals for normal metabolic function, resting membrane and action potentials, teeth and bones, buffers, osmotic balance, coenzymes, vitamins, and hemoglobin. Obtained from animal and plant.
USDA
united states department of agriculture, created health advisories for children for deficiencies. Made wheel, basic 4, hassle free guide, food pyramids, and choose my plate option.
Plasma cholesterol levels
livers produce it at a genetic basal level regardless, in response to saturated fatty acids stimulates cholesterol synthesis, and inhibits excretion. In response to unsaturated it makes more cholesterol and holds storage.
Trans fats
increase harmful low density lipoproteins and reduce helpful high density lipoproteins.
Unsaturated omega 3
fatty acids in cold water fish, there is lower saturated fat and cholesterol, helps with arrhythmias, clotting issues, and blood pressure issues.
Cholesterol
structural basis of steroids, bile salts, and vitamin D. transported via lipoproteins. Higher density used to transport excess cholesterol to liver and gets it to steroid producing endocrine glands.
Low density lipoproteins
transports cholesterol to the periphery. Helps with regulation of cholesterol synthesis.
Very low density lipoproteins
transports triglycerides to peripheral tissues and muscles.
LDL increase
changed by stress, smoking, and coffee consumption
HDL increase
aerobic exercise, estrogen
Excess dietary protein
excess amino acids are not stored in the body, they will be converted into an energy source and can become a fat storage. They don't exist as themselves, they are changed from transamination. Either from starvation or overeating protein.
Thermic effect of food
increases metabolism temporarily from the products of food.
Regulation of digestion
mechanical and chemical stimuli, intrinsic and extrinsic control, and depends on what you eat.
Gastric juice contains
gastrin, histamine, HCl, pepsinogen, intrinsic factor.
Phases of gastric secretions
cephalic, gastric, intestinal.
Digestion bottleneck
pyloric sphincter and duodenum are what can slow down the process.
Surface area modifications of the small intestine
plaicae circularis, villi, and microvilli.
Alkaline small intestine
either from the crypts or the pancreatic secretions will buffer the acid coming in from the stomach
Absorption starts
in the small intestine it begins the process with glucose absorbed in the GI tract. The glucose can move to muscles or tissues or liver or adipose, or the proteins can go to liver or adipose in a different form as fat.
Amino acids in liver
gets converted to proteins or keto acids/fatty acid/fat.
Insulin with increased blood glucose
controls absorptive state, its secretion is stimulated by blood glucose. Islet of Langerhans to make beta cells to increase insulin. Increases active transport of amino acids into tissues to make
Insulin control secretion stimulated by
elevated amino acid levels, increased blood glucose, or gastrin, CCK, or histamine secretions.
Post absorptive state
empty gut, catabolism replaces fluids in blood.
Brain fuel (stores and preference)
this organ prefers glucose, and there is no fuel storage in the brain.
Heart muscle fuel (stores and preference)
this organ prefers fatty acids, and stored as triglycerides
Adipose tissue fuel (stores and preference)
this tissue prefers fatty acids, and stored as triglycerides
Liver fuel (stores and preferences)
prefers to utilize fatty acids, glucose, and amino acids. The storage form would be triglycerides, glycogen, and protein.
Resting skeletal muscle fuel (stores and preferences)
prefers fatty acids and stores glycogen.
Active skeletal muscle fuel (stores and preference)
this organ prefers glucose and stores proteins
Insulin inhibits
cortisol release
Absorptive state occurs
gluconeogenesis, glycogenesis, lipogenesis
Post absorptive state occurs
glycolysis. Glucose breaks down storage fuels to make a constant glucose level to keep the brain alive.
Input
bond energy released from catabolizing food, metabolized in food intake,
Output
energy lost from heat of digestion (60%), energy used to do work, and storage energy.
Zerona low level lasers
gives normal fat cells repeated exposure to low level energy laser treatments that make the fat cells leak contents and shrinks, and the fat cells collapse and become flat. It was used to pretreat liposuction.
Food intake
two neurons in the hypothalamus LHA neurons promote hunger when stimulated by neuropeptides and VMN neurons tell the body it is full in response to CRH with appetite peptides.
Ghrelin
makes stomach growl, tells the body to eat
Glucagon
moves glucose into the blood
Epinephrine
moves glucose into the blood in a dangerous situation.
Neuropeptide Y
triggers a group of neurons to tell the body to get food.
Orexin
self arousal type neurons, tells the body to do something to go get food, scavenge, cook, etc.
Metabolism can be changed by
Temperature, stress, viral diseases, sleep deprivation
Exercise performance
consumed first is atp, then atp carbohydrates, then glycolysis, then aerobic respiration.
Catabolic hormones
glucagon, epinephrine, cortisol
Anabolic hormones
testosterone, growth hormone, IGF1, and insulin.
Insulin effects
increases protein synthesis, amino acid transport, glucose uptake, muscle glycogen storage, and muscle blood flow. inhibits protein degradation, cortisol release.
Sedentary with carbs
high carbs and lifestyle increases fat storage for this person because of insulin
Strength athlete
can benefit from the positive effects if you time the food intake to exercise correctly.
Nutrient timing Suzuki experiment
a post workout meal study would feed people immediately after exercise and fed after 4 hours. The results were that the immediate group got a 70% increase in fat oxidation enzymes and 24% decrease in abdominal fat. Compared with 4 hour later person
Nutrient timing esmerck experiment
measured insulin spikes for post workout meals immediately or 2 hours later. They found that muscle mass increased 8% and strength increased 15% for the immediate group. They used elderly people
At 3 years old
lack of proteins during fetal growth will show as intellectual disabilities later for kids.
Metabolic problems in kids
seem to occur later in development, except for insulin dependent diabetes myelitis.
Agents prescribed for age related medical problems
diuretics, antibiotics for bacteria in gut, mineral oil old treatment of constipation, excess alcohol consumption interferes with metabolism and vitamin deficiencies.
Non-enzymatic binding of glucose to proteins
increases risk with age, general stiffening of the tissues as well as the cloudiness of the eyes.
Urinary system function
filtration of the blood multiple times a day, excess is excreted as urine, reabsorption of nutrients.
Primary renal function
filters 200 liters of blood, removes toxins, removes metabolism waste, removes excess ions, regulates volume and chemical makeup, maintains proper water/salt/acid/base balance, site of gluconeogenesis from fasting, production of renin to regulate blood pressure, and production of erythropoietin to mature RBC, and activates vitamin D.
Kidneys
retroperitoneal organs, outside of the body cavity
Renal hilus
middle part of the kidney where blood vessels, lymphatics, nerves move in and out of the kidneys. (ureter attachment area)
3 layers of kidneys
renal capsule, adipose capsule, renal fascia
Renal capsule function
fibrous layer that helps protect the body from infection
Adipose capsule function
fatty mass layer that cushions the kidney, anchors it to body wall
Renal fascia function
outer dense connective tissue, fibrous, connects the kidney to the body wall.
Renal cortex
light colored, granular superficial region, glomeruli located here.
Renal medulla
contains renal columns that are inward extensions of cortical tissues that separate the pyramids which are collecting tubules, and medial to each pyramid is a papillae which is a drainage point.
Renal pelvis
innermost part of the kidney, collects urine from papillae and empties it into the pelvis.
Nephron
structural and functional unit of the kidney. cortical in cortex (85%) or juxtamedullary at medullary cortex junction. (15%)
Glomerular capillaries
afferent arteriole (larger diameter) goes to glomerulus to efferent arterioles (small diameter), moves arterioles of high resistance which makes efferent resistance higher, so this causes high blood pressure in the glomerulus which helps us form filtrate along the entire length of the glomerular capillaries.
Peritubular capillaries
wrapped around loop of Henle. low pressure capillaries that are adapted for absorption!! they arise from efferent arterioles and cling to renal tubules. They empty into the renal venous system.
Glomerular epithelium
fenestrated, allows solute rich and protein free filtrate to pass from blood into the bowman's capsule.
Bowman's capsule
parietal layer, mostly cuboidal cells. Keeps things together.
Visceral layer
(podocytes) these are support cells and have end processes with spaces for filtration slits. They regulate filtration.