BioPharm Remediation

the purpose of biopharmaceutics is to

understand the effect of drug properties, dosage form properties, administration conditions on drug delivery processes.

what is a drug

a chemical compound used in treatment or prevention of disease

a drug molecule binds to a … on the surface of cell, causing cell to react in a …. way

receptor protein, predictable

a drug molecule binds to a cell in body which causes immune cells to

destroy the cell or compound

a drug molecule binds to another compound in the body which causes the compound to be

inactivated

a drug molecule has direct

chemical action on body fluids or cells

whats a drug product

mixture of drugs with excipients in appropriate dosage form

what is an excipient

inactive ingredient

excipients have no …. but they have major influence on …

direct pharmacologic effect, drug delivery from the product

dosage form is

physical form of a drug product

examples of dosage forms

tablet, injection, transdermal patch

define drug delivery

a sequence of processes

first step in oral drug delivery

administer drug product

second step in oral drug delivery

drug molecules dissolve in GI fluid

3rd step in oral drug delivery

drug molecules absorbed into systemic blood circulation

4th step in oral drug delivery

drug molecules distribute throughout the body

5th step in oral drug delivery

elimination processes remove drug from body

define oral administration

swallowing drug product (tablet, capsule)

disintegration

tablet or capsule components dispersing in a liquid

define dissolution

molecules leave solid phase and enter solution phase

particles are not

absorbed, distributed via blood, metabolized or excreted

absorption is

transport of drug molecules from absorption site into presystemic circulation

Range for F-values

0-1

why would F be less than 1

presystemic metabolism, slow dissolution into GI fluid, very slow passive diffusion across SI, fast transport by intestinal epithelial efflux transporters, drug-drug interactions, chemical degradation in GI-Tract

how to calculate ABS value

p1 x A

How to calculate elimination column

P2(Abs + Bbeg)

How to calculate Bend column

ABS + Bbeg - ELIM

Ka on graph uses what to rank

Tmax

can you determine F from two non-IV doses

NO

dissolution rate is directly proportional to

solubility of drug in liquid and total SA of drug particles in the mixture

total surface area is inversely proportional to the

average particle size

electrolyte

compound that dissociates into ions in solution

ion

atom or molecule carrying electrostatic charge