CA 1: PHARMACOLOGY

PART 2

Sympathomimetic to the heart

Increases HR, Contractility

Sympathomimetic to the bronchus

Bronchodilation

Sympathomimeticc to the pupils

Mydriasis

Sympathomimetic to the GIT

Constipation

Sympathomimetic to the urinary bladder

Urinary retention

Sympathomimetic to the BV

Vasoconstriction

Sympatholytic to the heart

Decrease HR, Contractility

Sympatholytic to the Bronchus

Bronchoconstriction

Sympatholytic to the pupils

Miosis(Constrict)

Sympatholytic to the GIT

Diarrhea

Sympatholytic to the Bladder

Emptying the bladder

Sympatholytic to the BV

Vasodilation

Parasympathomimetic to the heart

Decreased HR, Contractility

Parasympathomimetic to the bronchus

Bronchoconstriction

Parasympathomimetic to the pupils

Miosis (Constrict)

Parasympathomimetic to the GIT

Diarrhea

Parasympathomimetic to the Urinary Bladder

Emptying the bladder

Parasympathomimetic to the BV

Vasodilation

Parasympatholytic to the heart, Sympathomimetic to the heart

Increase HR, Contractility

Parasympatholytic to the brochus

Bronchodilation

Parasympatholytic to the pupils

Mydriasis (dilate)

Parasympatholytic to the GIT

Constipation 

Parasympatholytic to the Urinary bladder

Urinary retention

Parasympatholytic to the BV

Vasoconstriction

Alpha 1 adrenergic agonist

It affects the Blood Vessels, Urinary Bladder, & Iris (Sympathomimetic)

Phenylephrine

Alpha 1 adrenergic agonist drug that has no effect in HR, Used for hypertension and eye exam (to keep pupils dilated)

Action of Phenylephrine

It is a decongestant (Neozep, Bioflu, symdex) which causes vasoconstrictions, decreases blood flow which shricks the cells. It is also a vasopressor (Inc. TPR & BP)

Alpha 2 Adrenergic Agonist

Used in hypertension

Alpha 2 Adrenergic agonist 

Affects the CNS nerve membrane (Decreased NE, weakeans SNS, PSNS response)

Also affects Pancreas (Decrease Insulin release → Hyperglycemia)

Clonidine (catapres)

An alpha 2 adrenergic agonist that crosses the BBB → Decreases Sympathetic effect, causing BP to decrease. 

Methyldopa

Used in Hypertension

Beta 1 Adrenergic agonist

SNS response to the heart and Kidney

Beta 2 adrenergic agonist

Found in Smooth muscle tissues (lungs, uterus, and GIT) and metabolic organs (Liver and skeletal muscles)

Albuterol/ Salbutamol is used for

Used for bronchoconstriction (asthma) and hyperkalemia (SABA)

Side effect of Ventolin

Palpitation and tremors

Albuterol/Salbutamol

Ventolin

Terbutaline

Beta 2 Adrenergic agonist that is used to treat asthma & COPD. It is also a tocolytic agent used for delay of delivery for preterm baby.

Formoterol

It is a LABA used to prevent future attacks of asthma.

Prazosin

Alpha 1 adrenergic antagonist used to treat hypertension

Doxazosin & Terazosin

Alpha 1 Adrenergic Antagonist used to treat hypertension and empties the bladder for BPH

Alfuzosin & Tamsulosin

Emptying of bladder → BPH

Phentolamine

Alpha adrenergic antagonist that causes vasodilation. Used for hypertensive crisis due to Pheochromocytoma (Tumor in AM)

Beta Adrenergic blockers

Propanolol, Timolol, Nadolol

Propanolol

A beta-adrenergic blocker that is used for tachycardia in hyperthyroidism, stage fright, and is as prophylaxis in migraine.

Timolol

A beta-adrenergic blocker that is used for open-angle glaucoma, by decreasing the production of aqueous fluid- Dec. Intraocular pressure

It is also a prophylaxis for migraine (EYE DROP)

Nadolol

A Beta adrenergic blocker  that is a DOC for angina + hypertension

Midodrine

Alpha Adrenergic agonist used to treat orthostatic hypotension