WEEK 15 QUALITY CONTROL

QUALITY CONTROL

IS A SYSTEM OF ENSURING ACCURACY AND PRECISION IN THE LABORATORY

IT IS THE PROCESS OF ENSURING ANALYTICAL RESULT ARE CORRECT

SAMPLE OR RESEMBLE PATIENT SAMPLE

IT IS THE PROCESS OF ENSURING ANALYTICAL RESULT ARE CORRECT BY TESTING THE?

SENSITIVITY

SPECIFICITY

SCCURACY

PRECISION OR REPRODUCIBILITY

PARAMETER OF QUALITY CONTROPARAMETER OF QUALITY CONTROLL

PARAMETER

NUMERICAL OR OTHER MEASURABLE FACTOR THAT DEFINES A SYSTEM

PRACTICABILITY

RELIABILITY

DIAGNOSTIC SENSITIVITY

DIAGNOSIS SPECIFICITY

PARAMETER OF QUALITY CONTROL (IMPORTANT TERM)

PRACTICABILITY

DEGREE BY WHICH A METHOD IS EASILY REPEATED

RELIABILITY

ABILITY OF AN ANALYTICAL METHOD TO MAINTAIN ACCURACY AND PRECIOS OVER AN EXTENDED PERIOD OF TIME DURING WHICH EQUIPMENT, REAGENT AND PERSONNEL MAY CHANGE

DIAGNOSTIC SENSITIVITY

It is the ability of the analytical method to detect the proportion of individuals with the disease

true-positive results

few false-negative

It indicates the ability of the test to generate more ___________ and ________

Screening tests

require high sensitivity so that no case is missed

DIAGNOSTIC SPECIFICITY

It is the ability of the analytical method to detect proportion of individuals without the disease

Reflects the ability of the method to detect true negatives with very few false positive

true negatives

very few false positive

Reflects the ability of the method to detect ________ with ________

Confirmatory tests

require high specificity to be certain of the diagnosis

Diagnostic Specificity and Sensitivity

100% sensitivity and specificity indicate that the test or method DETECTS every patient WITH the disease and that the test is NEGATIVE for every patient WITHOUT the disease

Intralab Quality Control (Internal QC)

Interlab Quality Control (External QC)

Kinds of Quality Control

Interlab Quality Control (External QC)

It involves proficiency testing programs that periodically provide samples of unknown concentrations to participating clinical laboratories

long-term accuracy

It is important in maintaining ________ of the analytical methods

Conduct of External QC Testing

A series of unknown samples are sent to the laboratory from the reference laboratory or authorized program provider

program provider

Unknown samples must be tested by the laboratorians who regularly perform analysis of patient specimens using the same reagents and equipment for actual patient specimens, and the results are submitted to the __________

Rationale of the External QC/Proficiency Testing

To ensure clinicians that patient results are accurate

Allows each laboratory to compare and evaluate test results or outcomes with those laboratories that used the same methods (reagents and equipment)