Fluoride PPT

Fluoride is rapidly absorbed as ________ through passive diffusion in the stomach: Rate and amount of absorption depend on the solubility of the fluoride compound and gastric acidity. Most is absorbed within ____ minutes.

hydrogen fluoride, 60

________ carries the fluoride for its distribution throughout the body and to the kidneys for elimination. Maximum blood levels are reached within ____ minutes of intake. Normal _____ levels are low and rise and fall according to intake.

Plasma, 30

Fluoride is distributed by the plasma to all tissues and organs. There is a

strong affinity for ________ .

mineralized tissues

________ is the adjustment of the natural fluoride ion content in a municipal water supply to the optimum physiologic concentration that will maximize caries prevention and limit enamel fluorosis.

Fluoridation

In 2015, the __________ updated the recommendation for the optimal concentration of water fluoridation to _____ for all communities, regardless of climate.

U.S. Department of Health and Human Services, 0.7 ppm

No more than _________ to be dispensed per household at one time.

264 mg NaF (120 mg fluoride ion)

____ NaF gel, ____ APF foam,  ____ NaF varnish,  ____ silver diamine fluoride (SDF)

2.0%,  1.23%, 5%, 38%

Concentrations of _______ fluoride or less can be sold OTC. Some products

containing more than _______ of fluoride are available only by Rx.

1,500 ppm

Fl2 mouthrinse contraindicated for: Children under _______ and those of any age who cannot rinse because of oral and/or facial musculature problems or other disability.

6 years of age

Dentist prescribes no more than ______ at one time (no more than 480 of the 0.25 mg tablets or 240 of the 0.5 mg tablets). Do not store large quantities in the home.

120 mg of fluoride

_______ is the amount of a drug likely to cause death if not intercepted by antidotal therapy.

Certainly lethal dose (CLD)A lethal dose

Whats the adult CLD for NaF?

Adult CLD: About 5–10 g of NaF taken at one time. The fluoride ion equivalent is 32–64 mg of fluoride per kilogram body weight (mg F/kg; Box 34-4A).

Whats the child CLD for NaF?

Child: Approximately 0.5–1.0 g, (5mg/kg of body weight) variable with size and weight of the child.

Whats the TSD and probable toxic dose?

Safely tolerated dose (STD): one-fourth of the CLD

Probably toxic dose: 5mg/kg of body weight

Whats the adult STD

• Adult STD: About 1.25–2.5 g of NaF (8–16 mg F/kg).

What are the signs and symptoms of acute toxic dose of fluoride?

-begins in 30 mins of ingestion and may persist for 24 hrs

-nausea, vomiting, and diarrhea

-abdominal pain

-increase salivation and thirst

-Blood: hypocalcemia

-CNS: Hyperreflexia, convulsions, and paresthesias

-cardio and respiratory depression (can lead to death)