Urinalysis AES Notes

 1. ureter- attached to each of the two kidneys, muscular tube, uses peristalsis to move the urine to the bladder
 2. bladder- hollow muscular sac. receives and stores urine
 3. kidney functions- filters blood to remove waste products from it, excrete waste products from the body, maintenance of blood pressure (blood pressure- how much force heart has to pump to transport blood around the body & electrolytes balance & blood pH- acid base balance, hydro-regulation
 4. kidneys structure- two bean-shaped organs on either side of the vertebral column (cortex &)
 5. kidney nephrons- tiny structures in the kidneys made up of glomerulus, bowman’s capsules, convoluted tubules, collecting tubules
 6. urine- aqueous waste product of human body’s metabolism of food, forms in nephrons of kidneys, contains urea, uric acid, creatinine (byproducts of proteins), ammonia (main byproduct of amino acids). salts, & mainly water as a solvent,
 7. random urine specimen- collected at any time of day or night; doesn’t yield consistent results
 8. mid-stream urine specimen- middle of urine stream
 9. first void urine specimen- first urine of the day, best bc concentrated

10. refrigerate urine- what to do if unable to analyze urine specimen immediately
11. 2 hrs- how long should urine be refrigerated
12. decomposes- what happens if urine is left out
13. 750-1500 ml/day- normal urine volume range
14. 1200-1500 ml- average urine volume range
15. polyuria- > 2500 ml/day (alcohol, caffeine, diuretic drugs, diabetes)
16. oliguria- < minimum range (dehydration, shock, renal failure, kidney stones, enlarged prostate)
17. anuria- no urine (renal failure)
18. \
        Urine Color Range
19. normal- straw-amber, avg: light to dark yellow, clear
20. red- presence of blood
21. orange-gold- bilirubin (liver damage)
22. white- pus, bacteria, UTI
23. black- malaria, malignant, melanoma
24. cloudy/turbid- WBC, bacteria, epithelial cells
25. hazy- mucous
26. smokey- RBCs
27. milky- fat, chyle (fat droplets)

red: fire

yellow: uncontrolled individual/threatening situation

blue: respiratory

green: designated people report to designated area

 1. specific gravity- indicates ability of kidney to concentrate urine (1.003-1.035, avg 1.015-1.025)
 2. hyposthenia- S.G. below 1.007 (hypertension, diabetes)
 3. hypersthenuria- S.G. above 1.030 (proteinuria)
 4. hyperglycemia- high level of glucose inside the blood
 5. 70-120 mg/dl- normal fasting blood glucose
 6. renal threshold- for glucose: 160-180 mg/dl: max amount of of glc that can be reabsorbed from renal filtrate, back into the blood stream
 7. glycosuria- due to hyperglycemia, when higher than renal threshold
 8. diabetes mellitus- most common disease associated with hyperglycemia + glycosuria, condition in which insulin is defective or produced in reduced amounts. Symptoms: polyuria, polydipsia polyphagia
 9. Insulin- produced by B cells in pancreas, allows glucose to enter cells, to produce energy necessary for cellular growth + metabolism, lack = hyperglycemia

10. ketones- substances formed from fats, when CH is not available, the body uses fats, then proteins as sources of energy. Fats (lipid molecules) produce fatty acids and glycerol which produce 3 ketones that can be detected in the urine.
11. severe ketosis- when insulin levels becomes out of control due to failure to take insulin, trauma. anxiety. pregnancy, infection. Patient becomes drowsy, dull, unconscious, may lapse into coma
12. ketonuria- ketones in urine
13. acetest tablet: sodium nitroprusside detects acetone and diacetic acid
14. ketonemia- excess of ketones in the blood, 2.0-40 mg/dl
15. acidosis- condition in which pH of blood drops, becomes more acidic
16. ketoacidosis/ketosis: when acidosis due to excess of ketones
17. ketosis- when no glucose is available, body breaks down fats for energy. ketones build up in the blood, resulting in this. diabetes mellitus, fad diet, starvation, vomiting, + diarrhea causes this
18. neurotoxicity- activity in the brain is depressed, can result in coma. and even death. pH of blood drops, respiration is adversely affected
19. proteinuria: “proteins in urine, significant indicator of renal disease.

    - causes glomerular damage (walls pf capillaries become more permeable and allow large molecules to pass through into urine filtrate). conditions associated with this: hypertension, diabetes mellitus, toxemia of pregnancy, UTI, glomerulonephritis (inflammation of glomerulus in nephrons)”

20. Liver: functions to help support metabolism, immunity, digestion, detoxification, vitamin storage (water soluble/lipid soluble)

    
    1. @@bile production@@: helps in absorption, digestion, and excretion of lipid molecules.
    2. ==fat-soluble vitamins==: storage and metabolism. Vit A.D.E.K.
    3. ==drug metabolism====:== and detoxification
    4. **==bilirubin ==**metabolism for excretion
    5. synthesis of ==plasma proteins==: albumin, globulins, protein C

21. Bilituin & Uribinogen

    
    1. products of RBC’s catabolism
    2. RBC avg lifespan: 90-120 days
    3. RBC’s→ Hemoglobin → Heme & globin → bilirubin
    4. Jaundice: excess of biliburin in blood
    5. jaundice: sin, sclera, and bail bed become yellow
    6. bilirubin is neurotoxic

       
       1. \