Exam 1: Pulgar-Adrenergic Antagonists

What will short term blood pressure regulation do?

Change in blood vessel, diameter, or change in heart rate, and contractility

How is it possible to change your blood vessel diameter?

The muscular tunica media of the arteries allows for rapid change and vessel diameter, because of sympathetic nerve stimulation

How can you regulate heart rate and contractility?

By changing vessel diameter, you can regulate total peripheral resistance;

MAP = TPR x CO

How can you regulate blood pressure long-term?

You can regulate the blood volume in the kidneys by activating the Ras system

What is an irreversible competitive alpha antagonist?

Phenoxybenzamine

What are the nonselective reversible antagonist for alpha-1 and alpha-2?

Phenylalanine and tolazoline

What are the alpha one selective reversible antagonist?

Prazosin

dozazosin

Terazosin

What are the alpha 1AD selective reversible, competitive antagonist?

Tamsulosin and silodosin

What receptors are responsible for the maintenance of total peripheral resistance in maintaining blood pressure?

Alpha one and alpha two Adrina receptors

Oh, which adrenalreceptors are the most efficacious and Lowering blood pressure?

Selective alpha-1

What is the alpha one select an antagonist use most often in hypertension therapy and also COPD?

Prazosin (minipress)

What is another used for alpha one selective antagonist?

BPH; Terazosin and tamsulosin are most often

What is the most often used for phenoxybenzamine the irreversible alpha antagonist?

Pheochromocytoma with her adrenal medullary, tumors where excess catecholamine production results in dangerously high blood

What class of drugs are the beta receptor antagonist?

Beta blockers

What alpha to antagonist is used to increase blood flow in erectile tissue in patients with ED?

Yohimbine

What are the nonselective beta blocker that block all three beta 1, 2, 3?

Propranolol, nadolol, timolol

What are the beta-1 receptors selective antagonist?

Metroprolol and atenolol

What are the beta and alpha one selective antagonist?

Labetalol and carvedilol these tend to have more antihypertensive effects

True or false: pharmalogical effect of a beta blocker, and a partial agonist or indistinguishable

True

What effect does a beta antagonist have on renin release?

Decreases

Blocking of which beta receptor is in general, most important in HTN?

Beta 1

What are the AE effects of beta antagonists?

Bradycardia, heart failure, angina after prolong therapy, bronchial, constriction, fatigue, and depression, increase triglycerides,

What are some important drive to drug interactions of beta antagonists?

Until one and rifampin increase plasma clearance of beta blockers; if used with CCBs, they enhance cardiac conduction defects; NSAIDs decrease effectiveness of beta blockers

Uses of beta antagonist

Hypertension, post MI, congestive heart failure, cardiac arrhythmias, migraine, prophylaxis, stage fright and glaucoma

What is a vasodilating beta blocker?

Reduce blood pressure, mainly due to reduction in PVR; ex carvedilol and labetalol

What is a non-vasodilating beta blocker?

Reduces blood pressure by reducing CO; ex./ atenolol, and metoprolol, and propranolol

What are the advantages of an vasodilating beta blocker?

Better glucose and look at control

What type of adrenergic med is propranolol?

Nonselective first generation, beta antagonist

What type of adrenergic med is phenoxybenzamine?

Nonselective, alpha one antagonist

What type is atenolol and metoprolol?

Second generation, beta, one selective

Give an example of a third generation, beta, selective antagonist

Nebivolol

Give a example of a nonselective, third generation, beta antagonist

Carvedilol and labetalol

What is the alpha-2 selective antagonist use for ED?

Yohimbine

The aplha 1 antagonist mostly end in ____?

"osin"