Neurology 342 - Attention Deficit Hyperactivity Disorder(ADHD)

- predominant inattentive type

- predominant hyperactive-impulsive type

- combined type

What are the types of ADHD?

social/academical/occupational activities

What do the symptoms of ADHD interfere with?

males

Who are more likely to be diagnosed with ADHD, males or females?

- genetics

- exposure to drugs during pregnancy, premature birth

- brain injury

What are the causes of ADHD?

imbalance of DA and NE

What is the neurochemistry of ADHD caused by?

low DA in limbic system

What is the hyperactive-impulsive type of ADHD low in?

low NE in PFC

What does inattentive type ADHD low in?

- adderall

- ritalin

- vyvanse

- methedrine

Name the different treatments for ADHD?

lisdexamfetamine

What is the generic name for Vyvanse?

methamphetamine

What is the generic name of methedrine?

pro-drug

- metabolized into D-amphetamine

Explain what type of drug Vyvanse is and what it's metabolized into?

2nd line treatment

What type of treatment would methedrine be used for?

oral administration

What is the instrumental use of methylphenidate(Ritalin)?

pills crushed to a powder and snorted

What is the recreational use of methylphenidate(Ritalin)?

low bioavailability

Does methylphenidate have a high or a low bioavailability?

false

True or false methylphenidate is broken down by the enzyme CYP450 in the liver?

~ 2-4 hours

What is the half life of methylphenidate?

Ritalinic acid

- inactive metabolite

What is methylphenidate(Ritalin) broken down into?

NE and DA reuptake inhibitor

- blocks NET and DAT

How does methylphenidate work?

college students

- aid for studying and energy

Who abuses methylphenidate(Ritalin) the most?

methylphenidate has a lower abuse liability

Which has a Lowe liability abuse when used recreationally between cocaine, amphetamines, or methylphenidate?