Week 2 Top 200 drugs

Azithromycin MOA

Binds to the 50S ribosomal subunit to inhibit bacterial protein synthesis.

Azithromycin Trade Names

Zithromax®/ Zmax™/ Z-pak®

Azithromycin Drug Class

Macrolide Antibiotic

Azithromycin FDA Indications

Chancroid

COPD (acute exacerbation)

Mycobacterium avium complex (MAC)

Otitis media (acute)

Pneumonia (community-acquired)

Rhinosinusitis (acute bacterial)

Skin and skin structure infections

Streptococcal pharyngitis

Urethritis/Cervicitis.

Cefdinir MOA

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Cefdinir Trade Name

Omnicef®

Cefdinir Drug Class

Third-Generation Cephalosporin Antibiotic

Cefdinir FDA Indications

COPD (acute exacerbation)

Otitis media (acute)

Pneumonia (community-acquired)

Rhinosinusitis (acute bacterial)

Skin and soft tissue infections

Streptococcal pharyngitis.

Cefuroxime MOA

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis.

Cefuroxime Trade Names

Ceftin®/ Zinacef®

Cefuroxime Drug Class

Second-Generation Cephalosporin

Cefuroxime FDA Indications (Oral)

COPD (acute exacerbation)

Lyme disease (early)

Otitis media (acute)

Sinusitis (acute bacterial)

Skin and skin structure infections

Streptococcal pharyngitis

UTIs

Cefuroxime FDA Indications (Injection)

Bone and joint infections

Lower respiratory tract infections

Septicemia

Skin and skin structure infections

Surgical prophylaxis

UTIs

Clindamycin MOA

Binds to the 50S ribosomal subunit to inhibit bacterial protein synthesis.

Clindamycin oral Trade Name

Cleocin®

Clindamycin Drug Class

Lincosamide Antibiotic

Clindamycin FDA Indications

Gynecological infections

Intra-abdominal infections

Lower respiratory tract infections

Septicemia

Skin and soft tissue infections

Metronidazole MOA

Forms reactive metabolites that disrupt bacterial DNA synthesis and cause strand breakage.

Metronidazole Trade Name

Flagyl®

Metronidazole Drug Class

Nitroimidazole Antibiotic, Antiprotozoal, Amebicide

Metronidazole FDA Indications

Amebiasis

Anaerobic Infections caused by Bacteroides spp. (Bone and joint infections, CNS infections, Endocarditis, Gynecologic infections, Intra-abdominal infections, Lower respiratory tract infections, Sepsis, Skin and skin structure infections)

Trichomoniasis

Nitrofurantoin MOA

Damages bacterial DNA through reactive intermediates formed after reduction within bacterial cells.

Nitrofurantoin Trade Name

Macrobid®

Nitrofurantoin Drug Class

Nitrofuran Antibiotic

Nitrofurantoin FDA Indications

Cystitis (acute), Cystitis (prophylaxis).