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The circulatory system
The heart
Blood vessels
Blood
What does blood carry
Oxygen
Glucose
Water
Hormones
Carbon Dioxide
Urea - Waste
Components of Blood
Red Blood cells
White Blood cells
Platelets
Plasma
Red Blood Cells
Red blood cells contain haemoglobin to carry oxygen
They have a large surface area for absorbing oxygen
No nucleus

White Blood Cells
White blood cells helps your body defend against pathogens
Lymphocyte - make antibodies
Phagocyte - goes round eating bacteria in the body
Have a nucleus

Platelets
Platelets help your blood clot and help the body form scabs to help wounds heal
Plasma
Fluid of blood, and helps with blood clotting
Plasma carries 4 substances: water, glucose, hormones, CO2
The process of blood clotting
Blood clotting is the process that stops bleeding when you get hurt
First, blood vessels tighten to reduce blood flow
Then tiny blood cells called platelets, stick to the injury + form a plug
Then a series of proteins in the blood work together to create fibrin, which forms a net that traps blood cells + helps the clot get stronger
This clot helps close the wound, and once the vessel is healed the clot breaks down naturally
blood under a light microscope and how to recognise components
Red blood cells - pink
Platelets - pale pink
White blood cells cytoplasm - pale blue
White blood cells nuclei - magenta
Blood Vessels
Vein:
Transports blood from the body’s organs back to the heart
They have thin walls + contain valves that stop the blood from flowing backwards
Blue, Deoxygenated blood
Capillary:
Allows substances to diffuse to/from blood/tissues
Connect the arteries to the vein
Artery:
Transports blood away from the heart at high pressure
They have thick walls to handle the high pressure from the heart’s pumping action
Red, Oxygenated blood
The heart diagram

Vena Cava Function
Deoxygenated
This vein carries blood into the heart from the body
Aorta Function
Oxygenated
This artery carries blood around the body
Pulmonary vein and Pulmonary artery function
Pulmonary vein -
oxygenated
This vein carries blood into the heart from the lungs
Pulmonary artery -
Deoxygenated
This artery carries blood to the lungs
Left atrium and Right atrium function
Left atrium -
Oxygenated
Pumps blood from the lungs to the left ventricle (has thin walls)
Right atrium -
Deoxygenated
Pumps oxygen to the right ventricle (has thin walls)
Valves Function
Oxygenated and Deoxygenated
Stop blood going backwards
Left ventricle and Right ventricle Function
Left ventricle -
Oxygenated
Pumps blood around the body (has thick walls)
Right ventricle -
Deoxygenated
Pumps blood to the lungs, where gas exchange takes place (has thick walls)
What does the heart do
The heart is an organ that pumps blood around the body in a double
circulatory system.
How does the heart uses its four chambers to pump blood around the body
Blood flows into the atria from the vena cava and the pulmonary vein
The atria contract, pushing the blood into the ventricles
The ventricles contract, forcing the blood into the pulmonary artery and the aorta, and out of the heart
The blood then flows to the organs through arteries, and returns through veins
The atria fill, and the whole cycle starts again over
Explain why an irregular heartbeat is detrimental to health
An irregular heart can make the heart less effective at pumping blood, which means the body doesn’t get enough oxygen. Which can lead to problems like stroke, heart failure, dizziness + fatigue. In severe cases, it can cause sudden heart failure. Treatment is important.
Different treatments for heart problems + their advantages and disadvantages
Advantages and disadvantages
Lifestyle Change:
No surgery or medicine needed
Helps prevent further heart problems
Improves overall health
Requires effort + consistency and takes time to show results
Medications:
Easy to take (pills or injections)
Quickly relieves symptoms
No surgery needed
May have side effects
Might be taken long-term
Coronary Artery Bypass Surgery:
Can solve serious artery blockages long-term
Improves quality of life
Long-term recovery
Risk of infection
Implantable devices (pacemakers, defibrillators):
Helps control heart rhythm
Can prevent heart failure
Requires surgery to implant
May need replacements or adjustments over time
Heart transplant:
Life saving
Improves long-term health
Donors are hard to find
Requires medication to prevent (ejections which can have side effects)
What happens in coronary heart disease
In coronary heart disease, layers of fatty material build up inside the coronary arteries, narrowing them. This reduces the flow of blood through the coronary arteries, resulting in a lack of oxygen for the heart muscle. Stents are used to keep the coronary arteries open. Statins are widely used to reduce blood cholesterol levels, which slows down the rate of fatty material deposit.
Stents and Statins
Stents:
Stents are small, tube-like dives used to keep passageways, like blood vessels, open. They are often used in cases of narrowed or blocked arteries to improve blood flow. (they can be made from metal)
Statins:
A Statin is a medicine that lowers bad cholesterol in your blood, it helps prevent problems like heart attacks + strokes by stopping your body from making too much cholesterol
Stents and statins advantages and disadvantages
advantages and disadvantages
Stents:
Restores blood flow, relieving symptoms like chest pain
Quick recovery
Long-term effectiveness
Prevents further blockage
Risk of complications (infection, bleeding)
Long-term medication
Re-narrowing of the artery
Not a cure
Statins:
lowers cholesterol + reduces heart disease risk
Well studied + cost-effective
Reduce inflammation
Risk of diabetes
Possible side effects (muscle pain, liver issues)
Lifelong treatment
Does not directly treat blockages
Why might people have objections to heart transplants
Religion + cultural
Cost
Fear of rejection
Medical risks
Can place too much of a strain on your organs
Artifical and Natural pasemakers
Natural:
The heart has a natural pacemakers called the SA node, located in the right atrium. It sends out electrical signals to start each heartbeat making sure the heart contracts reguarly. This node keeps a normal resting heart of 60-100 bpm which is important for good blood flow
Artificial:
An artificial pacemaker is a small device that helps your heart beat regularly. It uses a battery + wires to send electrical signals to your heart. This makes sure your heart beats at the right speed especially when your natural pacemaker isn’t working well
What are antitoxins
antibiotics