Neurotransmitters and Receptors

Receptors for acetylcholine

Muscarinic and Nicotinic

name 4 things that muscarinic receptors do

heart rate, smooth muscle contraction, glandular secretion, and cognitive functions

Muscarinic 1 - locations and 2 primary function

CNS, ganglia/ secretion from glands & cognitive processes

Muscarinic 2 - location

Smooth muscle,heart

muscarinic 2 functions

CNS, slows heart rate, inhibits neurotransmitter release

muscarinic 3 functions

Smooth muscle contraction (bronchoconstriction, bladder)
- Stimulates gland secretion (salivary, sweat)

Muscarinic 3 location

heart, smooth muscle, autonomic nerve terminals

nicotinic two type of receptors and locations

Nn - neuron of automatic ganglia /Nm- Skeletal muschle cells

BDNF

brain derived neurotropic factor-epigenetic changes reduce productionof BDNF, impacting neuronal growth and survival.

HPA

hypothalamic pituatary adrenal axis

Noradreneline - which is “auto-receptor” and its function

a2 - pre-synaptic and turn off Norepi release

norepi - a1 - 3 key functions

- Smooth muscle contraction (vasoconstriction in skin, kidneys, GI tract)
- Pupil dilation
- Increased blood pressure

norepi - a2- 3 key finctions

- Inhibits norepinephrine release (presynaptic feedback) - Reduces insulin secretion, increases glucagon - Platelet aggregation

norepi - b1 - key function

Gs

increases heartrate and contractibility - renin realease

where are 4 places b1 - norepi receptors

heart, kidney, fat cells, skeletal muscle

norepi b2 functions 4 functions

• Bronchodilation (airway smooth muscle relaxation)

• -Vasodilation in skeletal muscle
  - Glycogenolysis (liver), l

• lipolysis (fat)

where are b2 norepi receptors 7 places

blood vessels, bronchi, eye, GI, heart, kidney, skeletal muscle

b3 norepi function

metabolism

three GABA receptors

Ga, Gb, Gc

post synaptic dopamine receptors

D1 and D5 (excitatory and stimulate)

pre synaptic dopamine receptors

D2 and D3 - act as autoreceptors to further inhibit more dop release

Mesolimbic dopamine pathway

VTA to the NA

Mesocortical dopamine pathway

VTA to the cortex

Nigrastriatal dopamine pathway

substantia nigra to the striatum

Tuberoinfindibulator dopamine pathway

Hypothalamus to the pituatary

which is the only 5HT ion-gated

5HT3

lingand gated ion channels mediate by?

synaptic transmission

G-coupled work how?

intracellular singling cascade - metabotrophic