AP Bio Unit 6: Gene Expression and Regulation

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Pyrimidines

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69 Terms

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Pyrimidines

These base pairs have a single ring structure (U,C,T)

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Purines

These base pairs have a double ring structure (A,G)

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Semiconservative Replication

Each old DNA strand during replication pairs with a new one

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Plasmids

a genetic structure in a cell that can replicate independently of the chromosomes, typically a small circular DNA strand in the cytoplasm of a bacterium or protozoan. Plasmids are much used in the laboratory manipulation of gene

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Hydroxyl Terminus

Also known as the 3’ end of DNA. DNA is read from this end

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Phosphate Terminus

Also known as the 5’ end of DNA. Nucleotides are added from this end

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<p>Leading Strand</p>

Leading Strand

This strand is synthesized continuously during DNA replication

<p>This strand is synthesized continuously during DNA replication </p>
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<p>Lagging Strand</p>

Lagging Strand

This strand is synthesized discontinuously during DNA replication s it goes “backwards”

<p>This strand is synthesized discontinuously during DNA replication s it goes “backwards”</p>
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<p>Helicase</p>

Helicase

This enzyme unwinds DNA strands

<p>This enzyme unwinds DNA strands</p>
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<p>Topoismerase</p>

Topoismerase

This relaxes the supercoil at the replication fork

<p>This relaxes the supercoil at the replication fork</p>
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<p>Ligase</p>

Ligase

This enzyme acts as a “glue” to join fragments on the DNA lagging strand during replication

<p>This enzyme acts as a “glue” to join fragments on the DNA lagging strand during replication</p>
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<p>RNA Primase</p>

RNA Primase

This enzyme builds “chunks” of RNA on the lagging strand called Okazaki Fragments

<p>This enzyme builds “chunks” of RNA on the lagging strand called Okazaki Fragments</p>
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<p>Okazaki Fragments</p>

Okazaki Fragments

short sections of DNA formed at the time of discontinuous synthesis of the lagging strand during replication of DNA

<p>short sections of DNA formed at the time of discontinuous synthesis of the lagging strand during replication of DNA</p>
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mRNA

This type of RNA is a temporary RNA version of a DNA recipe

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DNA Replication

The act of copying DNA that happens during S Phase. This happens in the NUCLEUS

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RNA transcription

This is making an RNA copy of DNA

A tiny specific portion is made into mRNA on a gene by gene basis

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rRNA / Ribosomal

This type of RNA makes up ribosomes

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tRNA

This RNA shuttles amino acids to ribosomes and brings them into place

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Initiation, Elongation, Termination

The steps of RNA transcription

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AUG

Start Codon

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Antisense Strand

The template DNA being copied in RNA transcription

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Sense Strand / Coding Strand

The strand not being copied in RNA transcription

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RNA Polymerase

This enzyme adds RNA nucleotides to the 3’ side (building 5’ to 3’)

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Processed

In eurkaryotes, RNA must be ______ before leaving the nucleus

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Exons

Coding regions for proteinsI

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Introns

Non-coding regions of mRNA

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Spliceosome

Intron remover

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Poly(A) Tail

This is added to protect an mRNA strand with codons at the 3’ end

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GTP Cap

This is added to protect an mRNA strand with codons at the 5’ end

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Translation

Transforming an mRNA into a protein (on ribosomes in the cytoplasm and the rough ER)

Anti-codon of tRNA bonds with the mRNA codon

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Codon

A group of 3 nucleotides —> each represents an amino acid

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Anticodon

On the other end of tRNA opposite of the codon (3 complementary nitrogenous bases)

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Wobble Pairing

The third position of a codon is more flexible with pairing (ex: might pair G and U)

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A Site

This site on the Ribosome attaches new RNA

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P Site

This site on the Ribosome is in charge of creating the polypeptide

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E site

This site on a ribosome is the exit site

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Initiation

This is when RNA polymerase attaches to a promoter in transcription

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Elongation

This is when RNA polymerase makes the RNA strand during transcription

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Termination

When RNA polymerase leaves the DNA after completing transcription

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Initiation

In translation, this is when a ribosome attaches to mRNA

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Elongation

In translation, addition of amino acids (brought by tRNA). Link with peptide bonds

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Termination

In translation, when the ribosome reaches the end of an mRNA strand (stop codon)

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3

A ribosome reads mRNA in groups of ____ called codons

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Transcription Factors

These encourage or inhibit DNA unwinding and polymerase bonding

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Epigenetic Changes

These are changes to the DNA package (usually too tightly wrapped around histones, meaning that DNA cannot be read) caused by he environment

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Operons

In bacteria, a gene cluster is controlled by a single promoter

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Structural Genes

These code for enzymes

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Promoter Gene

RNA polymerase binds here to begin transcription

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Operator

This controls whether transcription occurs (IN BACTERIA)

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Regulatory Gene

This gene codes for a repressor (blocks transcription)

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Post-Transcriptional Regulation

In this gene regulation process, unneeded DNA is destroyed

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Post-Translational Regulation

In this gene regulation process, a cell makes a protein but does no use it

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Base Substitution / Point Mutations

A single nucleotide base is substituted for another

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Nonsense Mutation

When the original codon is replaced with a stop codon —> early termination

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Missense Mutation

The original codon is replaced with a different amino acid

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Silent Mutation

The original codon is replaced with a different one, but it still codes for the same amino acid

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Insertion / Deletion

A type of gene rearrangement: The gain or loss of DNA or a gene —> DEVASTATING CONSEQUENCES (frameshift)

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Frameshift

This gene rearrangement shifts how a sequence is read (sets of 3 become jumbled) and results from an insertion or deletion

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Duplications

A type of gene rearrangement: an extra copy of gene causes new traits and results from unequal crossing over

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Inversions

A type of gene rearrangement: change in orientation

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Translocation

A type of gene rearrangement: 2 chromosomes break and rejoin so DNA is lost / replaced / or interrupted

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Transposons

A type of gene rearrangement: gene segments are cut and pasted throughout a genome

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Conjugation

Bacteria swap DNA to create genetic diversity

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Recombinant DNA

A type of biotechnology: Combining DNA from multiple sources

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Polymerase Chain Reaction / PCR

A type of biotechnology: amplifying genes

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Transformation

A type of biotechnology: bacteria is induced to do something based off of a human gene (transcribe and translate)

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Gel Electrophoresis

A type of biotechnology: DNA fragments (alleles) are separated by weight and charge

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DNA Sequencing

A type of biotechnology: determining the order of nucleotides

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Alternative Splicing

a cellular process in which exons from the same gene are joined in different combinations

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