Histo slides w/ short descrip | Quizlet

Catarrhal Bronchopneumonia

· thick bronchide walls

· catarral exudate in alveoli lumen (RBCs, leukocytes + mucous)

· congested vessels

· edema separates good + bad

Fibrinous Bronchopneumonia => mosaic appearance

· Acute = capillaries congested + alveoli filled w/light pink fluid

· Red = alveoli filled w/ exudate = fibrin + RBCs

· Grey = lots of neutrophils in lumen

· Resolution = fibrin in strands due to neutrophils enz release

Bacterial embolic purulent nephritis

- bacterial emboli formed in capillary vessels and bv’s

- degen of tubular epi cells

- at edge of bacteria emboli => microabscess (neutrophils w/ debris)

Non-purulent encephalitis

- perivascular cuffing w/ lymphocytes of congested vessel

- increased glial cells => glialosis rosettes

- focal neuronal loss

- increased plasma + macrophages

Purulent encephalitis

- congestion of bv + neuronal degen

- perivascular cuffing + edema

- microabscess in necrotic brain tissue

Eosinophilic encephalitis

- MANY eosinophils in perivascular space

- cerebral edema => empty space around bvs + neurons

- neuronal degen + necrosis

Organisation of fibrin during post-traumatic pericarditis

- heart is covered in fibrin w/ vilious like projections

- young + old granulation tissue

- fat, inflam cells, myocardium

Chronic interstitial nephritis

- inflam (lymphocytes, plasma cells, macrophages) infiltrates in interstitial tissue

- hyperplasia of fibrous tissue

- retention cysts in lower parts of tubules

- atrophy of renal tubules

Chronic interstitial pneumonia

- thickened alveolar septa …narrowed lumen

- lymphoid follicles around bvs

- prolif of s.m cells

Pulmonary tuberculosis

- central necrosis surrounded by epitheloid cells w/ giant cells btw

- infiltrates of lymphocytes, plasma, fibrosis

Actinomycosis => Gram+ filamentous anaerobicrods

- accumulation of bacteria

- pyogranulomas separated w/ fibrous CT

- basophilic stained masses in centre .. surrounded with clubbed corona (eosinophilic material) then neutrophils then macrophages

Parasitic granuloma (of liver)

- dead parasites in centre surrounded by multinucleated giant cells

- regressive lesions of adjacent hepatocytes

Papilloma => benign epithelial neoplasm

- CT core w/ neoplastic squamous epi

- papilloma is thick bc… acanthotic, hyperplasia, hyperkeratotic

Cornified layer is vacuolated

Squamous cell carcinoma => malignant epithelial neoplasm

- irregular masses + cords proliferating downwards

- ulcerations on surface

- keratin pearls

- coag. necrosis

- mitotic figures + neoplastic cells

Adenoma => benign epithelial neoplasm

- tumour contains 1 layer of epi … neoplastic cells and cyst is empty

- hepatocytes @ edge + degen

- parenchyma is demarcated from liver tissue

- increased fibrous CT

Canine mammary carcinoma => simple tubular carcinoma

- neoplastic epi arranged tubular … 2 cell thick

- mitotic figures + nuclear pleomorphism

- neoplastic cells invade BM

Pulmonary metastasis of adenocarcinoma

- in alveoli and lymphatic system

- solid, papillary and tubular pattern

- metastasis nodules composed of neoplastic epi cells

Perianal gland tumour

- multilobulated masses

- basal reserve cells @ periphery lobules

- CT in stroma

Melanoma

- mitotic figures

- cellular cytoplasm … melanin pigment => Fontana staining

- nuclei pleomorphism + hyperchromasia

Fibroma

- whorls + interlacing bundles of fibroblasts, fibrocysts, collagen fibres

- may be firm or soft

- soft => fibromyxoma… collagen mixed w/ mutinous ground substance

Fibrosarcoma

- highly vascular but poorly formed

- interwoven ⭐️ immature fibroblasts

- collagen fibres

- nuclei elongated + mitotic figures

Feline injection site sarcoma FISS

- neoplastic spindle cells separated by fibromyxoma matrix (soft!)

- nuclei elongated + mitotic figures

- area of necrosis

- multinucleated giant cell

Lipoma

- mature adipocytes (appearance like normal fat)

- NO mitotic figures + rare CT w/ bvs

- nucleus eccentric (@ side)

Liposarcoma

- small + large adipocytes

- haemorrhages + necrosis

- highly cellular w/ mitotic figures

Mast cell tumour MCT

- cells in sheets + cords b/w collagen

- deep blue granules in cytoplasm

- round neoplastic cells are mixed w/ eosinophils

Lymphoma

- many lymphoblasts infiltrating muscle fibres => atrophy + degen

- mitotic figures

Hepatic coccidiosis … intracell parasites

- dilated bile ducts

- hyperplasia of biliary epi => papillary projections

- oocysts in lumen + inflam cells

- atrophy + degen

Hepatic echinococcus

- cystic structure lined with chitin mem

- may have protoscolices (parasite larvae)

- liver parenchyma => atrophy, fatty degen, necrosis, haemorrhage

- infiltrate cells: macrophages, epitheliod cells and giant cells

Hepatic fascioliasis

- coag. necrosis + haemorrhages

- hemosiderin pigments + inflam cells

- fibrosis @ portal area

- prolif of biliary ducts

- scar formation in migration pathway

Parasitic pneumonia

- distended alveoli, bronchi + bronchioles

- degenerated + mononuclear cells

- s.m + epi hyperplasia … thickened alveolar septa

- exudate + emphysema … congestion

Trichinellosis

- Early: parasite within myocytes +infiltrate cells

- Late: normal morph w/ thick capsule and possible accumulation of Ca salt

Contagious Bovine Pleuropneumonia (CBPP)

- fibrous pneumonia = acute, red, grey (increase neutrophils), resolution

- area of necrosis w/ bv @ centre + inflam cells surrounding

- marginal organisation…. granulation grows to surviving lobes

Equine Infectious Anemia (EIA)

- necrosis of central lobes

- congestion of c.v + sinuses

- hemosiderin + inflam cells in triad

- hyperplasia of Browicz-Kupfur cells

Infectious Canine Hepatitis (ICH)

- hepatic necrosis

- congestion + inflam infiltrate

- intranuclear viral inclusion bodies (basophilic)

Canine Distemper Virus (CDV)

- interstitial pneumonia => narrow lumen

- bacterial/catarrhal-purulent bronchopneumonia => inflam cells in bronchioles + alveoli

- intracellular viral inclusion bodies

Feline Panleukopenia.... catarrhal inflam of intestinal mm

- looks like worm on slide

- fibrin accumulation + crypt necrosis

- hemoarrhages + inflam cells

- basophilic intranuclear inclusion bodies in crypt epi