Virology Final Exam

Class I dsDNA Virus

Herpes Simplex Virus (HSV)

Ganciclovir is primarily used to treat infections caused by which of the following?

CMV

Ivermectin is an antiviral that binds to what herpes entry receptor, blocking the virus from entering?

Importin-B

Which Herpes viral family member causes sixth disease?

HHV-6

The tegument is located between which two structures?

Capsid and Envelope

What receptors/coreceptors do HSV spike proteins bind to?

HVEM and Heparan Sulfate receptors (A and C)

Class II ssDNA virus

Parvovirus B19

What is the primary receptor for Parvovirus B19?

P antigen

Which disease is classically caused by Parvovirus B19 in children?

Erythema infectiosum (Fifth Disease)

Which mechanism does Parvovirus B19 use to replicate its genome?

Rolling-Hairpin replication

Which portion of the Parvovirus B19 genome acts as a primer for the formation of intermediate dsDNA?

Inverted Terminal Repeats (ITRs)

Which of these is NOT a treatment for Parvovirus B19?

Parvovirus vaccine

Class III dsRNA virus

Blue Tongue Virus (BTV)

Which protein assembles the viral inclusion bodies?

NS2

What kind of vaccine is used to prevent BTV?

Live attenuated

What is the main form of transmission for BTV?

Midges

What cell type does BTV target?

Endothelial and Immune

Which protein(s) are responsible for the virus's antigenicity?

VP2 and VP5 (Both A and B)

Class IV + ssRNA virus

Poliovirus

What was the cause of the Cutter incident?

Improper reproduction of vaccine

What receptor binds to the capsid proteins on the poliovirus?

CD-155

What gene is not used in the protein complex used for viral replication?

2A

What is the mechanism for endocytosis?

Tyrosine Kinase

Which treatment for polio is no longer used today?

Iron Lung

Class V - ssRNA virus

Rabies

Who was the first person successfully treated with Louis Pasteur's rabies vaccine in 1885?

Joseph Meister

How many deaths happen per year due to the virus?

59,000

Which of the following is NOT associated with the rabies virus RNP complex?

Glycoprotein (G)

How is human rabies treated?

Wound treatment, HRIG, and Rabies vaccinations

How does rabies virus exit the host cell?

Budding through the plasma membrane regions enriched with G protein.

Class VI RT RNA virus

HIV

Where does HIV maturation occur?

Outside the cell

The third drug used in HIV therapy may be?

Fusion inhibitor, Integrase inhibitor, protease inhibitor (all of the above)

Which protein is cleaved to make gp41 and gp120?

Gp160

How long after entering the CD4+ T cell does RT begin making cDNA?

1-2 hours

Which regulatory protein enhances the transcription of viral RNA?

Tat

Class VII RT DNA

Hepatitis B

Which of these is a class VII pararetrovirus?

Hepatitis B

Higher risk of hepatitis B transmission is associated with all of the following EXCEPT:

Sharing forks

How many genotypes does Hepatitis B have?

10

Where does chronic hepatitis B reside in the nucleus?

cccDNA episome and Within host genome (Both A and B)

Which of these viruses have a vaccine available for them?

Hepatitis A and B