EXAM TWO chapter 13 (not done)

bodys response to periodontal pathogens

cause of nearly all destruction in periodontitis (presence of pathogens alone is not enough to cause destruction)

Virulence factors

this ones chunky but idk how to break it up

all the mechanisms that enable biofilm to colonize and damage tissues. can be structural or substances released (presense of lipopolysaccharides, ability to invade tissue, ability to produce enzymes)

catabasis

return back to homeostasis

E2 prostaglandin?

worst prostaglandin for perio disease?

cytokines

signal immune system to send more phagocytes to site of infection.
can initiate tissue destruction and bone loss in chronic infection

Prostaglandins

i am confusion
need to know- initiate most alveolar bone destruction

metrix metalloproteinases (MMPs)

breakdown connective tissue matrix, facilitate normal turnover in health,
released to kill invading bacteria, overproduction leads to breakdown connective tissue

genetic and environmental factors

modify inflammatory response

1. Initial lesion (come back to this)

bacterial accumulation/colonization by gingival margin

2. Early lesion: early gingivitis (come back to this)

-bacteria continue to grow/mature, get into connective tissue
-MMPs are responsible for 60-60% of loss of connective tissue

3. Established Lesion: Established gingivitis (come back to this)

disrupts attachment

4. Advanced lesion: periodontitis (come back to this)

Lateral spread, pge2 initiate bone destruction, chronic inflammation