CHEM 3410 Chapter 6: Protein Structure

0.0(0)
studied byStudied by 0 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Get a hint
Hint

What determines a protein's activity and capability?

Get a hint
Hint

Its 3D shape, which is the structure its 'string of amino acids' adopts.

Get a hint
Hint

What are the four levels of protein structure?

Get a hint
Hint

Primary, secondary, tertiary, and quaternary.

Card Sorting

1/18

flashcard set

Earn XP

Description and Tags

Flashcards covering key concepts from the lecture notes on protein structure, including levels of structure, determining forces, secondary structures, tertiary structure, quaternary structure and protein denaturing.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

19 Terms

1
New cards

What determines a protein's activity and capability?

Its 3D shape, which is the structure its 'string of amino acids' adopts.

2
New cards

What are the four levels of protein structure?

Primary, secondary, tertiary, and quaternary.

3
New cards

What dictates the primary structure of a protein?

Covalent bonds between the amino acids.

4
New cards

What interactions determine the higher order structural features of proteins?

Non-covalent interactions.

5
New cards

What is the driving force that folds a protein into its 3D shape?

Hydrophobic interactions.

6
New cards

Where are charged residues typically located in a protein?

On the protein surface, interacting with water.

7
New cards

What type of covalent bond can form between two cysteine residues?

A disulfide bridge.

8
New cards

Where does all the information necessary to fold a protein into its unique 3D shape come from?

Its primary structure.

9
New cards

What property gives the amide bond some characteristics of a rigid, 'flat', double bond?

Its resonance properties.

10
New cards

What are the two common types of secondary structures in proteins?

Alpha-helix and beta-sheet.

11
New cards

What is the structure of alpha-helix?

A part of a single strand of amino acids coils itself into a helical shape.

12
New cards

How are alpha helices formed?

Through hydrogen bonds between peptide groups that are about 3.6 amino acids apart.

13
New cards

In beta-sheet, how are two or more segments of separate strands of amino acid aligned?

Side-by-side so that hydrogen bonds can form between peptide groups that are close to each other.

14
New cards

What are the names for the 3D shape of the entire protein?

Tertiary structure.

15
New cards

What are molecular chaperones also known as?

Heat shock proteins.

16
New cards

What is quaternary structure?

The assembly of multiple individual proteins into a single functional complex.

17
New cards

What type of interactions hold the individual components of quaternary structure together?

Weak, secondary interactions.

18
New cards

What happens during protein denaturing?

The disruption of the weak forces within the protein structure without breaking the covalent bonds.

19
New cards

Name methods that can cause Protein denaturing

Heating, changes in pH, adding organic solvents, adding salts, adding detergents, adding chaotropic agents