CSU BMS 302 EXAM 1

law of diffusion equation

Q=[Ya-Yb]xTyx(Sy/sqrtMwy)XA/D

Na+ concentration gradient and permeability

Out to in, not permeable

K+ perm/grad

In to out, perm

A- perm/grad

In to out, not perm

Cl- perm/grad

out to in, perm

excitability

ability to generate AP

conductivity

ability to propagate AP

Action potential steps

Before myosin can bind to active binding site, it must be in high E state. What happens>

ATPase in myosin head hydrolyzes ATP from previous relax cycle

Muscle potential steps

1. Stim motor neuron - AP
2. Ach from axon to cleft
3, Ach binds receptors on sarcolemma
4. Na moves through chem gated channels
5. Na voltage gated channels, Na floods in
6. Action potentials to Ttubules
7. SR depolarizes and releases Ca
8. Ca binds troponin

muscle fiber organization

fascicle - fiber - myofibril - myofilaments

somatic (1/2, ganglion, NT, effector)

1, no, ach, skel musc

autonomic

2, yes, ach and ne, smooth, cardiac, glands

Symp NT, short long pre

ach , NE, short preganglion

Parasymp NT, length

ACh, long

skel musc latent period
duration of contraction
caclium
excitation

3 msec, ms, SR, nervous

Visc smooth much
latent period
duration
ca
excitation

200-300 msec
seconds
extracellular
pacemaker, cell to cell junctions

Visceral smooth rhythm
AND
innervation

yes, modifies, not all fibers innervated

multiunit smooth muscle

no rhythm, ANS initiates, each fiber innervated

norepi/epi on ileum

inhib

ach on ileum

stim

atropine on ileum

none

norepi/epi

ad ag

ach

chol ag

atropine

chol antag

chol agon on ileum

stim

ad ag on ileum

inhib

cholinergic

parasymp

adrenergic

symp

medulla

secretes epi

procaine

reduces AP amp, prevents NA voltage opening