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Growth Hormone (GH)
A hormone that promotes growth in cells and tissues.
Adrenal glucocorticoid hormones
Hormones produced in the adrenal cortex that regulate metabolism and the immune response.
Thyroid hormones
Hormones produced by the thyroid gland that regulate metabolism.
Pituitary gland
An endocrine gland located at the base of the brain that controls other endocrine glands.
Hypothalamus
A region of the brain that regulates the pituitary gland.
Hypophysial stalk
The stalk that connects the hypothalamus to the pituitary gland.
Anterior pituitary (adenohypophysis)
The front part of the pituitary gland that produces numerous hormones.
Posterior pituitary (neurohypophysis)
The back part of the pituitary gland that stores and releases hormones produced by the hypothalamus.
Releasing hormones
Hormones secreted by the hypothalamus that stimulate the anterior pituitary to release its hormones.
Adrenocorticotropin (ACTH)
A hormone from the anterior pituitary that stimulates cortisol production in the adrenal cortex.
Thyroid-stimulating hormone (TSH)
A hormone that stimulates the thyroid gland to produce thyroid hormones.
Follicle-stimulating hormone (FSH)
A hormone that stimulates growth of ovarian follicles in females and sperm production in males.
Leutenizing Hormone (LH)
A hormone that triggers ovulation and stimulates testosterone production.
Prolactin (PRL)
A hormone that promotes breast development and milk production.
Somatotropes
Cells in the anterior pituitary that produce growth hormone.
Thyrotropes
Cells in the anterior pituitary that produce thyroid-stimulating hormone.
Gonadotropes
Cells that produce gonadotropic hormones, FSH and LH.
Lactotropes
Cells that produce prolactin.
Corticotropes
Cells that produce adrenocorticotropic hormone (ACTH).
Pro-opiomelanocortin (POMC)
A precursor protein that is cleaved to produce several hormones including ACTH.
Hypothalamic-hypophysial portal system
A system of blood vessels connecting the hypothalamus and the anterior pituitary.
Growth hormone-releasing hormone (GHRH)
A hormone that stimulates the release of growth hormone from the anterior pituitary.
Corticotropin-releasing hormone (CRH)
A hormone that stimulates the release of ACTH from the anterior pituitary.
Thyroid-stimulating hormone-releasing hormone (TRH)
A hormone that promotes the release of TSH from the anterior pituitary.
Gonadotropin-releasing hormone (GnRH)
A hormone that stimulates the release of FSH and LH from the anterior pituitary.
Prolactin inhibitory hormone (PIH)
A hormone that inhibits the release of prolactin.
Somatotropin
Another name for growth hormone.
Insulin sensitivity
The effectiveness of insulin in promoting glucose uptake.
Diabetogenic hormone
Hormones, like GH, that can lead to increased blood glucose levels.
Insulin resistance
A condition in which cells fail to respond effectively to insulin.
Insulin secretion
The process of releasing insulin from pancreatic beta cells.
Growth factors
Substances that promote cellular growth and development.
Insulin-like growth factors (IGFs)
Proteins that mediate the effects of growth hormone on growth.
Dwarfism
A condition resulting from GH deficiency during childhood.
Giantism
A condition characterized by excessive growth due to GH overproduction before adolescence.
Acromegaly
A condition caused by excessive GH secretion after adolescence leading to growth of soft tissues.
Laron dwarfs
Individuals with a genetic defect in the GH receptor causing dwarfism.
Hypoglycemia
Abnormally low blood sugar levels.
Hyperinsulinemia
Excess levels of insulin in the blood.
Cardiac hypertrophy
Enlargement of the heart muscle.
Visceral enlargement
Increased size of internal organs due to excess GH.
Shortened life expectancy
Reduced expected lifespan due to health conditions like acromegaly.
Joint problems
Issues in the joints often associated with excessive growth and pressure.
Laryngeal growth
Growth of the larynx, often leading to a deeper voice in individuals with acromegaly.