What controls insulin secretion? – Beta cells sense glucose

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9 Terms

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1)

Glucose enters Beta Cells by facilitated diffusion via GLUT-2

<p>Glucose enters Beta Cells by facilitated diffusion via GLUT-2</p>
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2)

Glucose is phosphorylated to glucose-6-phosphate

<p>Glucose is phosphorylated to glucose-6-phosphate</p>
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3)

oxidation of glucose-6-phosphate generates ATP

<p>oxidation of glucose-6-phosphate generates ATP</p>
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4)

ATP acts on ATP-sensitive K channels, closing it

<p>ATP acts on ATP-sensitive K channels, closing it</p>
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5)

reduced exit of K depolarizes mem.

<p>reduced exit of K depolarizes mem.</p>
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6)

depolarization opens voltage-gated Ca channels

<p>depolarization opens voltage-gated Ca channels</p>
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7)

Ca enters Beta Cells

<p>Ca enters Beta Cells</p>
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8)

Ca triggers exocytosis of insulin vesciles

<p>Ca triggers exocytosis of insulin vesciles</p>
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9)

insulin is secreted

<p>insulin is secreted</p>