What is delta naming of fatty acids?
#totalCarbons:#ofDBCarbonsΔ^(PositionofDB)
What are the structural lipids?
Phopholipids and Sphingolipids
What are the properties of a phospholipid?
Polar headgroup, glycerol, 2 FA tails; amphiphatic for lipid bilayer
What are the properties of sphingolipids
Amphiphatic for membrane, used in cell-signaling
What Lipid is used for long term energy storage?
Triacylglycerols
What is the effect of TAGS being neutral and hydrophobic?
Allows packing and doesn’t interupt cell processes
How are TAGS broken down?
Hydrolyzed by Lipases for energy production in Beta-Oxidation
What are the 3 signaling lipids?
Sterols, Eicosanoids, and Glycerphospholipids
What are the properties of sterols?
Long range signaling and affects membrane properties
What are the properties of eicosanoids?
Short term Signaling, not in blood
What are the properties of glycerophopholipids?
Polar headgroup and 2 FA tails; used to activate secondary messengers.
Do longer or shorter FA tails increase fluidity?
Shorter due to less VDW interactions
Do saturated or unsaturated FAs increase fluidity?
Unsaturated
How does temperature affect membrane fluidity?
Hot → Inc fluidity, Cold → Dec fluidity
How are lipids transported through blood?
Lipoproteins
Why are membranes asymmetrical?
Allows certain domains and functions on each side of the membrane
What effects does membrane assymetry allow?
Electric encironments, structure and biological regulation, prevents PS on outer leaflet (Phagocytosis)
How does flippase move lipids?
Outer leaflet to Inner leaflet
How does Floppase move lipids?
Inner leaflet to outer leaflet
How does Scramblase move lipids?
Evenly distributes lipids, disrupts assymetry; activated by Ca2+ damage marker for phagocytosis
What are the relative speeds of transverse and lateral diffusion?
Transverse is slow, lateral is fast
How do integral membrane proteins exist?
In membrane
How do peripheral membrane proteins exist?
Associate with one leaflet
How do amphitrophic membrane proteins exist
Associate reversibly
What is the difference between mono, bi, and polytopic membrane proteins?
Mono → Goes through one leaflet, Bi → goes through both leaflets, Poly → goes through both leaflets many times
What is simple diffusion?
Nonpolar compounds moving down a concentration gradient
What is facilitated diffusion?
Compounds moving down electrochemical gradient
What is primary active transport
Moves against EC gradient using ATP
What is Ionophore mediated ion transport?
Moves down EC gradient
What are ion channels?
Ions moving down EC Gradient
What is secondary active transport?
Moving against EC Gradient by ion movement