Module 4 Additional Practice

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1
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<p><span>True or false? After binding a signaling molecule, an EGF receptor can activate RAS.</span></p>

True or false? After binding a signaling molecule, an EGF receptor can activate RAS.

True

2
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<p><span>True or false? Once activated, RAS can directly activate MAPKKK.</span></p>

True or false? Once activated, RAS can directly activate MAPKKK.

True

3
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<p><span>True or false? MAPKKK indirectly inhibits the activity of MAPKK.</span></p>

True or false? MAPKKK indirectly inhibits the activity of MAPKK.

False

4
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<p><span>True or false? Once activated, MAPKK can directly activate MAPK.</span></p>

True or false? Once activated, MAPKK can directly activate MAPK.

True

5
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<p><span>True or false? Once activated, MAPK enters the nucleus and inhibits the activity of ETS1.</span></p>

True or false? Once activated, MAPK enters the nucleus and inhibits the activity of ETS1.

False

6
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<p><span>True or false? Once activated, MAPK can directly activate paxillin.</span></p>

True or false? Once activated, MAPK can directly activate paxillin.

True

7
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<p><span>True or false? Once activated, MAPK can directly activate MAPKK.</span></p>

True or false? Once activated, MAPK can directly activate MAPKK.

False

8
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<p><span>True or false? Once activated, ETS1 can affect gene expression.</span></p>

True or false? Once activated, ETS1 can affect gene expression.

True

9
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<p><span>True or false? Every kinase in this signaling pathway can amplify the signal initiated by EGF.</span></p>

True or false? Every kinase in this signaling pathway can amplify the signal initiated by EGF.

True

10
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<p><span>Which protein directly activates MAPKKK?&nbsp;</span></p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKK</span></p></li><li><p><span>d. MAPK</span></p></li><li><p><span>e. paxillin</span></p></li><li><p><span>f. ETS1</span></p></li></ul><p></p>

Which protein directly activates MAPKKK? 

  • a. EGF receptor

  • b. RAS

  • c. MAPKK

  • d. MAPK

  • e. paxillin

  • f. ETS1

  • b. RAS

11
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<p>Which molecules indirectly activate MAPKKK? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKK</span></p></li><li><p><span>d. MAPK</span></p></li><li><p><span>e. paxillin</span></p></li><li><p><span>f. ETS1</span></p></li></ul><p></p>

Which molecules indirectly activate MAPKKK? Select all that apply.

  • a. EGF receptor

  • b. RAS

  • c. MAPKK

  • d. MAPK

  • e. paxillin

  • f. ETS1

  • a. EGF receptor

12
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<p>Which molecule directly activates MAPK?&nbsp;</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKKK</span></p></li><li><p><span>d. MAPKK</span></p></li><li><p><span>e. paxillin</span></p></li><li><p><span>f. ETS1</span></p></li></ul><p></p>

Which molecule directly activates MAPK? 

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

  • e. paxillin

  • f. ETS1

  • d. MAPKK

13
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<p>Which molecules indirectly activate MAPK? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKKK</span></p></li><li><p><span>d. MAPKK</span></p></li><li><p><span>e. paxillin</span></p></li><li><p><span>f. ETS1</span></p></li></ul><p></p>

Which molecules indirectly activate MAPK? Select all that apply.

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

  • e. paxillin

  • f. ETS1

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

14
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<p>Which molecules indirectly activates paxillin? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKKK</span></p></li><li><p><span>d. MAPKK</span></p></li><li><p><span>e. MAPK</span></p></li><li><p><span>f. ETS1</span></p></li></ul><p></p>

Which molecules indirectly activates paxillin? Select all that apply.

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

  • e. MAPK

  • f. ETS1

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

15
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<p>Which molecule directly activates ETS1?&nbsp;</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKKK</span></p></li><li><p><span>d. MAPKK</span></p></li><li><p><span>e. MAPK</span></p></li><li><p><span>f. paxillin</span></p></li></ul><p></p>

Which molecule directly activates ETS1? 

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

  • e. MAPK

  • f. paxillin

  • e. MAPK

16
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<p>Which molecules are indirectly activated by the EGF receptor? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. RAS</span></p></li><li><p><span>b. MAPKKK</span></p></li><li><p><span>c. MAPKK</span></p></li><li><p><span>d. MAPK</span></p></li><li><p><span>e. ETS1</span></p></li></ul><p></p>

Which molecules are indirectly activated by the EGF receptor? Select all that apply.

  • a. RAS

  • b. MAPKKK

  • c. MAPKK

  • d. MAPK

  • e. ETS1

  • b. MAPKKK

  • c. MAPKK

  • d. MAPK

  • e. ETS1

17
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<p>Which molecule can directly affect gene expression?</p><ul><li><p><span>a. EGF receptor</span></p></li><li><p><span>b. RAS</span></p></li><li><p><span>c. MAPKKK</span></p></li><li><p><span>d. MAPKK</span></p></li><li><p><span>e. MAPK</span></p></li><li><p><span>f. paxillin</span></p></li><li><p><span>g. ETS1</span></p></li></ul><p></p>

Which molecule can directly affect gene expression?

  • a. EGF receptor

  • b. RAS

  • c. MAPKKK

  • d. MAPKK

  • e. MAPK

  • f. paxillin

  • g. ETS1

  • e. MAPK

18
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<p>Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot A (top left plot) of the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Pathway 1 (Receptor → L → M → N → O)</span></p></li><li><p><span>b.&nbsp;Pathway 2 (Receptor → L → O → N → M)</span></p></li><li><p><span>c. Pathway 3 (Receptor → O → L → M → N)</span></p></li><li><p><span>d. Pathway 4 (Receptor → N → M → O → L)</span></p></li></ul><p></p>

Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot A (top left plot) of the top figure? Select all that apply.

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

  • d. Pathway 4 (Receptor → N → M → O → L)

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

19
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<p>Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot B (top right plot) of the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Pathway 1 (Receptor → L → M → N → O)</span></p></li><li><p><span>b.&nbsp;Pathway 2 (Receptor → L → O → N → M)</span></p></li><li><p><span>c. Pathway 3 (Receptor → O → L → M → N)</span></p></li><li><p><span>d. Pathway 4 (Receptor → N → M → O → L)</span></p></li></ul><p></p>

Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot B (top right plot) of the top figure? Select all that apply.

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

  • d. Pathway 4 (Receptor → N → M → O → L)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

20
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<p>Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot C (bottom left plot) of the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Pathway 1 (Receptor → L → M → N → O)</span></p></li><li><p><span>b.&nbsp;Pathway 2 (Receptor → L → O → N → M)</span></p></li><li><p><span>c. Pathway 3 (Receptor → O → L → M → N)</span></p></li><li><p><span>d. Pathway 4 (Receptor → N → M → O → L)</span></p></li></ul><p></p>

Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot C (bottom left plot) of the top figure? Select all that apply.

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

  • d. Pathway 4 (Receptor → N → M → O → L)

  • a. Pathway 1 (Receptor → L → M → N → O)

  • c. Pathway 3 (Receptor → O → L → M → N)

21
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<p>Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot D (bottom right plot) of the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Pathway 1 (Receptor → L → M → N → O)</span></p></li><li><p><span>b.&nbsp;Pathway 2 (Receptor → L → O → N → M)</span></p></li><li><p><span>c. Pathway 3 (Receptor → O → L → M → N)</span></p></li><li><p><span>d. Pathway 4 (Receptor → N → M → O → L)</span></p></li></ul><p></p>

Which signaling pathways in the bottom figure (1 through 4) are consistent with the data in Plot D (bottom right plot) of the top figure? Select all that apply.

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

  • d. Pathway 4 (Receptor → N → M → O → L)

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

22
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<p>Which signaling pathway (1 through 4) in the bottom figure is consistent with the data in the top figure?&nbsp;</p><ul><li><p><span>a. Pathway 1 (Receptor → L → M → N → O)</span></p></li><li><p><span>b. Pathway 2 (Receptor → L → O → N → M)</span></p></li><li><p><span>c. Pathway 3 (Receptor → O → L → M → N)</span></p></li><li><p><span>d. Pathway 4 (Receptor → N → M → O → L)</span></p></li></ul><p></p>

Which signaling pathway (1 through 4) in the bottom figure is consistent with the data in the top figure? 

  • a. Pathway 1 (Receptor → L → M → N → O)

  • b. Pathway 2 (Receptor → L → O → N → M)

  • c. Pathway 3 (Receptor → O → L → M → N)

  • d. Pathway 4 (Receptor → N → M → O → L)

  • d. Pathway 4 (Receptor → N → M → O → L)

23
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<p>Which plots (A through D) in the bottom figure support the relationships shown in the EGF signaling pathway in the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Plot A</span></p></li><li><p><span>b. Plot B</span></p></li><li><p><span>c. Plot C</span></p></li><li><p><span>d. Plot D</span></p></li></ul><p></p>

Which plots (A through D) in the bottom figure support the relationships shown in the EGF signaling pathway in the top figure? Select all that apply.

  • a. Plot A

  • b. Plot B

  • c. Plot C

  • d. Plot D

  • a. Plot A

  • b. Plot B

24
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<p>Which plots (A through D) in the bottom figure are consistent with the model of the signaling pathway in the top figure? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. Plot A</span></p></li><li><p><span>b. Plot B</span></p></li><li><p><span>c. Plot C</span></p></li><li><p><span>d. Plot D</span></p></li></ul><p></p>

Which plots (A through D) in the bottom figure are consistent with the model of the signaling pathway in the top figure? Select all that apply.

  • a. Plot A

  • b. Plot B

  • c. Plot C

  • d. Plot D

  • d. Plot D

25
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<p>Which proteins <strong>directly</strong> terminate this signaling pathway by inhibiting TGF-𝛃 receptor? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. TGF-𝛃r</span></p></li><li><p><span>b. SMAD2</span></p></li><li><p><span>c. SMAD3</span></p></li><li><p><span>d. SMAD4</span></p></li><li><p><span>e. SMAD7</span></p></li></ul><p></p>

Which proteins directly terminate this signaling pathway by inhibiting TGF-𝛃 receptor? Select all that apply.

  • a. TGF-𝛃r

  • b. SMAD2

  • c. SMAD3

  • d. SMAD4

  • e. SMAD7

  • e. SMAD7

26
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<p>Which processes <strong>directly</strong> reduces the activity of proteins in this signaling pathway? Select <strong>all</strong> that apply.</p><ul><li><p><span>a.&nbsp;phosphorylation of SMAD2 and SMAD3 by a TGF-𝛃 receptor</span></p></li><li><p><span>b. dephosphorylation of SMAD2 and SMAD3 by a TGF-𝛃 receptor</span></p></li><li><p><span>c.&nbsp;activation of a TGF-𝛃 receptor by SMAD7</span></p></li><li><p><span>d.&nbsp;inhibition of a TGF-𝛃 receptor by SMAD7</span></p></li></ul><p></p>

Which processes directly reduces the activity of proteins in this signaling pathway? Select all that apply.

  • a. phosphorylation of SMAD2 and SMAD3 by a TGF-𝛃 receptor

  • b. dephosphorylation of SMAD2 and SMAD3 by a TGF-𝛃 receptor

  • c. activation of a TGF-𝛃 receptor by SMAD7

  • d. inhibition of a TGF-𝛃 receptor by SMAD7

  • d. inhibition of a TGF-𝛃 receptor by SMAD7

27
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<p>True or false? When a signaling molecule activates a TGF-𝛃 receptor, SMAD7 immediately inhibits the activity of the TGF-𝛃 receptor.</p><ul><li><p><span>a. true</span></p></li><li><p><span>b. false</span></p></li><li><p><br></p></li></ul><p></p>

True or false? When a signaling molecule activates a TGF-𝛃 receptor, SMAD7 immediately inhibits the activity of the TGF-𝛃 receptor.

  • a. true

  • b. false


False

28
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<p>True or false?&nbsp;SMAD7 indirectly decreases the abundance of phosphorylated SMAD2 by inhibiting the activity of a TGF-𝛃 receptor.</p><ul><li><p><span>a. true</span></p></li><li><p><span>b. false</span></p></li></ul><p></p>

True or false? SMAD7 indirectly decreases the abundance of phosphorylated SMAD2 by inhibiting the activity of a TGF-𝛃 receptor.

  • a. true

  • b. false

True

29
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<p>True or false?&nbsp;Inhibition of gene expression would completely eliminate negative feedback in this signaling pathway.&nbsp;</p><ul><li><p><span>a. true</span></p></li><li><p><span>b. false</span></p></li></ul><p></p>

True or false? Inhibition of gene expression would completely eliminate negative feedback in this signaling pathway. 

  • a. true

  • b. false

True

30
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<p>True or false?&nbsp;Inhibition of SMAD7 would increase the abundance of phosphorylated SMAD3 in the presence of TGF-𝛃.</p><ul><li><p><span>a. true</span></p></li><li><p><span>b. false</span></p></li></ul><p></p>

True or false? Inhibition of SMAD7 would increase the abundance of phosphorylated SMAD3 in the presence of TGF-𝛃.

  • a. true

  • b. false

True

31
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<p>Which relationship describes the effect of negative feedback on the phosphorylation of SMAD2?&nbsp;</p><ul><li><p><span>a. Relationship A</span></p></li><li><p><span>b. Relationship B</span></p></li><li><p><span>c. Relationship C</span></p></li></ul><p></p>

Which relationship describes the effect of negative feedback on the phosphorylation of SMAD2? 

  • a. Relationship A

  • b. Relationship B

  • c. Relationship C

  • c. Relationship C

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<p>Which relationship would describe the phosphorylation of SMAD2 if gene expression were partially inhibited by a drug?</p><ul><li><p><span>a. Relationship A</span></p></li><li><p><span>b. Relationship B</span></p></li><li><p><span>c. Relationship C</span></p></li></ul><p></p>

Which relationship would describe the phosphorylation of SMAD2 if gene expression were partially inhibited by a drug?

  • a. Relationship A

  • b. Relationship B

  • c. Relationship C

  • b. Relationship B

33
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<p>Which cellular responses should occur in the presence of Wnt and the absence of insulin? Select <strong>all </strong>that apply.</p><ul><li><p><span>a. activation of Dvl</span></p></li><li><p><span>b. inhibition of Dvl</span></p></li><li><p><span>c. activation of β-cat</span></p></li><li><p><span>d. inhibition of β-cat</span></p></li><li><p><span>e. β-cat binds to TCF)</span></p></li><li><p><span>f. activation of IRS</span></p></li><li><p><span>g. inhibition of IRS</span></p></li><li><p><span>h. activation of PI3K</span></p></li><li><p><span>i. inhibition of PI3K</span></p></li><li><p><span>j. activation of AKT</span></p></li><li><p><span>k. inhibition of AKT</span></p></li><li><p><span>l. activation of mTOR</span></p></li><li><p><span>m. inhibition of mTOR</span></p></li><li><p><span>n. gene expression</span></p></li></ul><p></p>

Which cellular responses should occur in the presence of Wnt and the absence of insulin? Select all that apply.

  • a. activation of Dvl

  • b. inhibition of Dvl

  • c. activation of β-cat

  • d. inhibition of β-cat

  • e. β-cat binds to TCF)

  • f. activation of IRS

  • g. inhibition of IRS

  • h. activation of PI3K

  • i. inhibition of PI3K

  • j. activation of AKT

  • k. inhibition of AKT

  • l. activation of mTOR

  • m. inhibition of mTOR

  • n. gene expression

  • a. activation of Dvl

  • c. activation of β-cat

  • e. β-cat binds to TCF)

  • n. gene expression

34
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<p>Which cellular responses should occur in the presence of insulin and absence of Wnt? Select <strong>all</strong> that apply.</p><ul><li><p><span>a. activation of Dvl&nbsp;</span></p></li><li><p><span>b. inhibition of Dvl&nbsp;</span></p></li><li><p><span>c. activation of β-cat</span></p></li><li><p><span>d. inhibition of β-cat</span></p></li><li><p><span>e. β-cat binds to TCF</span></p></li><li><p><span>f. activation of IRS</span></p></li><li><p><span>g. inhibition of IRS</span></p></li><li><p><span>h. activation of PI3K</span></p></li><li><p><span>i. inhibition of PI3K</span></p></li><li><p><span>j. activation of AKT</span></p></li><li><p><span>k. inhibition of AKT</span></p></li><li><p><span>l. activation of mTOR</span></p></li><li><p><span>m. inhibition of mTOR</span></p></li><li><p><span>n. gene expression</span></p></li></ul><p></p>

Which cellular responses should occur in the presence of insulin and absence of Wnt? Select all that apply.

  • a. activation of Dvl 

  • b. inhibition of Dvl 

  • c. activation of β-cat

  • d. inhibition of β-cat

  • e. β-cat binds to TCF

  • f. activation of IRS

  • g. inhibition of IRS

  • h. activation of PI3K

  • i. inhibition of PI3K

  • j. activation of AKT

  • k. inhibition of AKT

  • l. activation of mTOR

  • m. inhibition of mTOR

  • n. gene expression

  • c. activation of β-cat

  • e. β-cat binds to TCF

  • f. activation of IRS

  • h. activation of PI3K

  • j. activation of AKT

  • l. activation of mTOR

  • n. gene expression

35
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<p>Which cellular responses should occur in the presence of both Wnt and insulin?&nbsp;Select <strong>all</strong> that apply.</p><ul><li><p><span>a. activation of Dvl</span></p></li><li><p><span>b. inhibition of Dvl&nbsp;</span></p></li><li><p><span>c. activation of β-cat&nbsp;</span></p></li><li><p><span>d. inhibition of β-cat</span></p></li><li><p><span>e. β-cat binds to TCF</span></p></li><li><p><span>f. activation of IRS</span></p></li><li><p><span>g. inhibition of IRS</span></p></li><li><p><span>h. activation of PI3K</span></p></li><li><p><span>i. inhibition of PI3K</span></p></li><li><p><span>j. activation of AKT</span></p></li><li><p><span>k. inhibition of AKT</span></p></li><li><p><span>l. activation of mTOR</span></p></li><li><p><span>m. inhibition of mTOR</span></p></li><li><p><span>n. gene expression</span></p></li></ul><p></p>

Which cellular responses should occur in the presence of both Wnt and insulin? Select all that apply.

  • a. activation of Dvl

  • b. inhibition of Dvl 

  • c. activation of β-cat 

  • d. inhibition of β-cat

  • e. β-cat binds to TCF

  • f. activation of IRS

  • g. inhibition of IRS

  • h. activation of PI3K

  • i. inhibition of PI3K

  • j. activation of AKT

  • k. inhibition of AKT

  • l. activation of mTOR

  • m. inhibition of mTOR

  • n. gene expression

  • a. activation of Dvl

  • c. activation of β-cat 

  • e. β-cat binds to TCF

  • f. activation of IRS

  • h. activation of PI3K

  • j. activation of AKT

  • l. activation of mTOR

  • n. gene expression

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<p>Which row of the table (A through D) contains the combination of signaling molecules needed to produce the cellular response shown in the figure?</p><ul><li><p><span>a. Row A</span></p></li><li><p><span>b. Row B</span></p></li><li><p><span>c. Row C</span></p></li><li><p><span>d. Row D</span></p></li></ul><p></p>

Which row of the table (A through D) contains the combination of signaling molecules needed to produce the cellular response shown in the figure?

  • a. Row A

  • b. Row B

  • c. Row C

  • d. Row D

  • b. Row B

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<p>Complete the following sentence. If PTH binds to receptors in the membrane of an osteoblast, the activity of MAPK in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If PTH binds to receptors in the membrane of an osteoblast, the activity of MAPK in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

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<p>Complete the following sentence. If PTH binds to receptors in the membrane of an osteoblast, the concentration of calcium ions (Ca<sup>2+</sup>) in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If PTH binds to receptors in the membrane of an osteoblast, the concentration of calcium ions (Ca2+) in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

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<p>Complete the following sentence. If the activity of MAPKK in an osteoblast increases, the concentration of RANKL in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the activity of MAPKK in an osteoblast increases, the concentration of RANKL in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

40
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<p>Complete the following sentence. If the concentration of RANKL in osteoblasts increases, a bone would release Ca<sup>2+</sup> at _______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of RANKL in osteoblasts increases, a bone would release Ca2+ at _______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • a. a faster rate

41
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<p>Complete the following sentence. If calcitonin binds to receptors in the membrane of an osteoblast, the activity of MAPKK in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If calcitonin binds to receptors in the membrane of an osteoblast, the activity of MAPKK in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

42
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<p>Complete the following sentence. If calcitonin binds to receptors in the membrane of an osteoblast, the concentration of Ca<sup>2+</sup> in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If calcitonin binds to receptors in the membrane of an osteoblast, the concentration of Ca2+ in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

43
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<p>Complete the following sentence. If the concentration of Ca<sup>2+</sup> in an osteoblast increases, the concentration of OPG in that cell would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of Ca2+ in an osteoblast increases, the concentration of OPG in that cell would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

44
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<p>Complete the following sentence. If the concentration of OPG in osteoblasts increases, a bone would release calcium ions at _______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of OPG in osteoblasts increases, a bone would release calcium ions at _______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • b. a slower rate

45
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the activity of calcitonin receptors would ______</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the activity of calcitonin receptors would ______

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

46
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the concentration of Ca<sup>2+</sup> in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the concentration of Ca2+ in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

47
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the concentration of OPG in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the concentration of OPG in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

48
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the activity of PTH receptors would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the activity of PTH receptors would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

49
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the activity of MAPKK in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the activity of MAPKK in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

50
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the concentration of RANKL in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the concentration of RANKL in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

51
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, the activity of RANK receptors would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, the activity of RANK receptors would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

52
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too low, a bone would release Ca<sup>2+</sup> at ______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too low, a bone would release Ca2+ at ______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • a. a faster rate

53
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the activity of calcitonin receptors would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the activity of calcitonin receptors would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

54
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the concentration of Ca<sup>2+</sup> in an osteoblast would ______.&nbsp;</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the concentration of Ca2+ in an osteoblast would ______. 

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

55
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the concentration of OPG in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the concentration of OPG in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

56
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the activity of PTH receptors would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the activity of PTH receptors would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

57
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the activity of MAPKK in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the activity of MAPKK in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

58
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the concentration of RANKL in an osteoblast would ______.&nbsp;</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the concentration of RANKL in an osteoblast would ______. 

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

59
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, the activity of RANK receptors would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, the activity of RANK receptors would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

60
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<p>Complete the following sentence. If the concentration of calcium ions (Ca<sup>2+</sup>) in the blood became too high, a bone would release Ca<sup>2+</sup> at ______.&nbsp;</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. If the concentration of calcium ions (Ca2+) in the blood became too high, a bone would release Ca2+ at ______. 

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

b. a slower rate

61
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<p>Complete the following sentence. If the number of PTH receptors increased, the concentration of Ca<sup>2+</sup> in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the number of PTH receptors increased, the concentration of Ca2+ in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

62
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<p>Complete the following sentence. If the number of PTH receptors increased, the concentration of OPG in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the number of PTH receptors increased, the concentration of OPG in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

63
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<p>Complete the following sentence. If the number of PTH receptors increased, the activity of MAPKK in an osteoblast would ______.&nbsp;</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the number of PTH receptors increased, the activity of MAPKK in an osteoblast would ______. 

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

64
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<p>Complete the following sentence. If the number of PTH receptors increased, the concentration of RANKL in an osteoblast would ______.</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. If the number of PTH receptors increased, the concentration of RANKL in an osteoblast would ______.

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

65
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<p>Complete the following sentence. If the number of PTH receptors increased, a bone would release Ca<sup>2+</sup> at ______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. If the number of PTH receptors increased, a bone would release Ca2+ at ______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • a. a faster rate

66
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<p>Which relationship accurately represents the expected relationship if the concentration of RANKL remains constant?</p><ul><li><p><span>a. Relationship A</span></p></li><li><p><span>b. Relationship B</span></p></li><li><p><span>c. Relationship C</span></p></li></ul><p></p>

Which relationship accurately represents the expected relationship if the concentration of RANKL remains constant?

  • a. Relationship A

  • b. Relationship B

  • c. Relationship C

  • c. Relationship C

67
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<p>Which relationship would best represent the expected relationship if the concentration of RANKL were to change proportionally to the concentration OPG?</p><ul><li><p><span>a. Relationship A</span></p></li><li><p><span>b. Relationship B</span></p></li><li><p><span>c. Relationship C</span></p></li></ul><p></p>

Which relationship would best represent the expected relationship if the concentration of RANKL were to change proportionally to the concentration OPG?

  • a. Relationship A

  • b. Relationship B

  • c. Relationship C

  • b. Relationship B

68
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<p>Which line accurately describes the expected relationship?&nbsp;&nbsp;</p><ul><li><p><span>a. Line A</span></p></li><li><p><span>b. Line B</span></p></li><li><p><span>c. Line C</span></p></li></ul><p></p>

Which line accurately describes the expected relationship?  

  • a. Line A

  • b. Line B

  • c. Line C

  • a. Line A

69
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<p>The graph shows three potential relationships between the concentration of estrogen and the concentration of OPG.&nbsp;</p><p>Which line accurately describes the expected relationship?&nbsp;&nbsp;</p><ul><li><p><span>a. Line A</span></p></li><li><p><span>b. Line B</span></p></li><li><p><span>c. Line C</span></p></li></ul><p></p>

The graph shows three potential relationships between the concentration of estrogen and the concentration of OPG. 

Which line accurately describes the expected relationship?  

  • a. Line A

  • b. Line B

  • c. Line C

  • a. Line A

70
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, the concentration of calcium ions (Ca<sup>2+</sup>) in an osteoblast should ______ .</p><ul><li><p><span>a.&nbsp;increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, the concentration of calcium ions (Ca2+) in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

71
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of MAPKK in an osteoblast should ______ .</p><ul><li><p>a.&nbsp;increase</p></li><li><p>b. decrease</p></li><li><p>c. remain the same</p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of MAPKK in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

72
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of PLC in an osteoblast should ______ .</p><ul><li><p><span>a.&nbsp;increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of PLC in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

73
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, the concentration of RANKL in an osteoblast should ______ .</p><ul><li><p><span>a.&nbsp;increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, the concentration of RANKL in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

74
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of RANK receptors in the membrane of an osteoclast should ______ .</p><ul><li><p><span>a.&nbsp;increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, the activity of RANK receptors in the membrane of an osteoclast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

75
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<p>Complete the following sentence. As the concentration of estrogen increases during pregnancy, a bone would release Ca<sup>2+ </sup>at _______.</p><ul><li><p><span>a.&nbsp;a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases during pregnancy, a bone would release Ca2+ at _______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • b. a slower rate

76
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, the concentration of calcitonin in the blood should ______ .</p><ul><li><p><span>a.&nbsp;increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, the concentration of calcitonin in the blood should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

77
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, the concentration of calcium ions (Ca<sup>2+</sup>) in an osteoblast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, the concentration of calcium ions (Ca2+) in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

78
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of IP<sub>3</sub> in an osteoblast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of IP3 in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

79
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of MAPKKK in an osteoblast should ______ .</p><p>a. increase</p><p>b. decrease</p><p>c. remain the same</p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of MAPKKK in an osteoblast should ______ .

a. increase

b. decrease

c. remain the same

c. remain the same

80
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of CaMK in an osteoblast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, the activity of CaMK in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

81
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<p>Complete the following sentence. As the concentration of estrogen decreases during pregnancy, the activity of RANK receptors in the membrane of an osteoclast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during pregnancy, the activity of RANK receptors in the membrane of an osteoclast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

82
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<p>Complete the following sentence. As the concentration of estrogen decreases during menopause, a bone would release Ca<sup>2+</sup> at _______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen decreases during menopause, a bone would release Ca2+ at _______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • a. a faster rate

83
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<p>Complete the following sentence. As the concentration of estrogen increases through medication, the concentration of OPG in an osteoblast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases through medication, the concentration of OPG in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • a. increase

84
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<p>Complete the following sentence. As the concentration of estrogen increases through medication, the concentration of RANKL in an osteoblast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases through medication, the concentration of RANKL in an osteoblast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • c. remain the same

85
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<p>Complete the following sentence. As the concentration of estrogen increases through medication, the activity of RANK receptors in the membrane of an osteoclast should ______ .</p><ul><li><p><span>a. increase</span></p></li><li><p><span>b. decrease</span></p></li><li><p><span>c. remain the same</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases through medication, the activity of RANK receptors in the membrane of an osteoclast should ______ .

  • a. increase

  • b. decrease

  • c. remain the same

  • b. decrease

86
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<p>Complete the following sentence. As the concentration of estrogen increases through medication, a bone would release Ca<sup>2+</sup> at _______.</p><ul><li><p><span>a. a faster rate</span></p></li><li><p><span>b. a slower rate</span></p></li><li><p><span>c. the same rate</span></p></li></ul><p></p>

Complete the following sentence. As the concentration of estrogen increases through medication, a bone would release Ca2+ at _______.

  • a. a faster rate

  • b. a slower rate

  • c. the same rate

  • b. a slower rate

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