DNA
a polymer composed of 2 polynucleotide chains that form a double helix carrying genetic instructions
histones
dna wraps around _______ (think of fargo and the mouse)
shape DNA
histones are proteins that help maintain the _____ of chromosomes and aid in the tight packing of ___
nucleosome
dna wrapped around an octet of histones is called a…
allosomes
sex chromosomes are also called
autosomes
somatic/body chromosomes are also called
XX
females
XY
males
44
how many autosomes does a human normally have
22
how many pairs of autosomes does a human normally have
karyotype
a chromosome map is called a
body 46
somatic cells are ____ cells and have __ chromosomes
reproductive 23
gametes are _________ cells and have __ chromosomes
2
diploid cells have how many sets of chromosomes
2n
diploid cells are abbreviated as
1
a haploid cell has _ set of chromosomes
sperm and egg
what kind of cells are haploid?
n
how are haploid cells abbreviated
46 46 diploid 2n 23 haploid 1n 46
think of the little picture we drew: the girls body was __, boys body was __, those were _______ and __, and the egg and sperm were __ and ________ and __, and the egg plus sperm made another human that was __
down syndrome
extra 21st chromosome is
turner syndrome
females lacking 1 x chromosome is
klinefelter’s syndrome
have XXY is
patau syndrome
extra 13th chromosome is
47, XY, +21
karyotype of a male with down syndrome
47, XY, +13
karyotype of male with patau syndrome
interphase prophase metaphase anaphase telophase cytokinesis G1 S G2
write out the whole cell cycle
okay!!
look at your woobie for the specifics of what is happening in each part of the cell cycle!!
bacteria
an example of prokaryotes is
binary fission
the division of a prokaryotic cell into two identical offspring cells aka asexual reproduction
g1 g2 g1 mitosis
when a g1 cell is fused with an s-phase cell, DNA replication happens in the __ nucleus, probably because of s-cdk activity in the s cell. BUT g2 with an s phase does not mean dna synthesis in __. SO only __ cells can do dna replicate and that cells that did s phase (otherwise known as g2 cells) can’t re-replicate their dna even when they are given some s-cdk acticity. SO going through ______ is required for the cell to be able to go through s phase again.
washing machine g1 g0
we compared the cell control system to a…. meaning there are different checkpoints to go through. if it doesnt go through the checkpoint at __, it will go into a nondividing state called __
cdk cyclins
cyclin dependent kinases (or ___) are enzymes, and their activity fluctuates bc they’re controlled by _______, which are called that bc their concentrations vary with the cell cycle
mpf g2
maturation promoting factor (___) is a cyclin-cdk that triggers a cells passage past the __ checkpoint into mitosis
spindle apparatus anaphase
internal signal example: kinetochores not attached to ______ _________ and this delays _______
growth factors
external signal example: ______ _______ (proteins released by certain cells that tell other cells to divide)
crowded cells stop dividing
density dependent inhibition is where
uncontrolled cell replication
what is cancer?
substration
anchorage dependence means cells must be attached to a ________ to dividide
growth
cancer cells do not have density dependent inhibition or anchorage dependence, they’re also super weird about ______ factors
transformation
normal cell → cancer cell
noncancerous metasize
benign tumor: abnormal but ________ mass of cells that lacks the ability to invade neighboring tissue (aka _________)
malignant tumor
the tendency of tumors to become progressively worse and maybe result in death
metastasis
spread of a cancer from one organ to another NON ADJACENT organ