Stem Cells Flashcards

Vocabulary flashcards for stem cell research review.

SCNTs (NT-SCs)

Nuclear Transfer Stem Cells. Look to lesson 20 for slides on how they are made and used in reproductive cloning.

Teratoma

Tumors that form from sperm or egg germ cells and tend to differentiate and make tissues from all lineages; used to test pluripotency of stem cells.

iPSCs

Induced Pluripotent Stem Cells - reprogrammed somatic cells that become pluripotent stem cells.

Autologous Transplant

Transplant where the patient donates their own stem cells, receives chemo, and then has their own HSCs put back in. Pro: no immune response. Con: cancer can come back.

Allogenic Transplant

Transplant where the donor gets mobilization of HSCs, the host receives a giant chemo dose, and then donor stem cells are put into the host. Pro: new immune system. Con: risk of Graft vs. Host Disease (GvHD).

WI-38 cells

Lung-derived fibroblasts (unipotent stem cells) from a legally aborted fetus in Sweden in 1962, used in vaccine development (Hep A, Rubella, Chickenpox, Shingles, Rabies).

Efficacy (in clinical trials)

Focus of Phase 2 and 3 clinical trials. Does the treatment actually work?