Germinal Centres and Affinity Maturation
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10 Terms
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Where do germinal centres form?
B cell follicles in lymph nodes
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What enzyme derives somatic hypermutation?
AID (activation-induced deaminase)
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What is somatic hypermutation?
Point mutations in Ig V regions
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What is affinity maturation?
Selection of high-afifinity antibodies
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What cells present intact antigen in GCs?
Follicular dendritic cells (FDC)
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What do centroblasts do?
Proliferate and mutate Ig genes
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What do centrocytes do?
Compete for antigen and T cell help
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What happens to low affinity B cells?
Apoptosis
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What is the role of TFH cells?
Provide help to GC B cells
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What are the outcomes of GC reactions?
Plasma cells, memory B cells or death
Note 
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