negative feedback loops + difference between T1D & T2D

increase in blood glucose - negative feedback loop

stimulates pancreas to secrete insulin

increase in circulatory insulin

increase uptake of glucose by cells

* increases metabolic energy
* increases fat synthesis
* increase glycogen synthesis

decrease in blood glucose

decrease in blood glucose - negative feedback loop

stimulates pancreas to secrete glucagon

increases circulating glucagon

breakdown of glycogen in liver

release of glucose into bloodstream

negative feedback loop - T1D

increase in blood glucose concentration

destruction of beta cells prevents detection and release of insulin

* glucose is not removed from bloodstream

negative feedback loop - T2D

increase in blood glucose concentration

change detected by beta cells

insulin released

insulin sensitivity prevents insulin from acting effectively on receptors

* glucose is not removed from bloodstream

diabetes type 1 - definition

destruction of beta cells

auto-immune response

some genetic influence

lack of insulin secretion

diagnosis age - 14 years old

diabetes type 2 - definition

gradual development of insulin resistance

some genetic influence

some influence from increase in age and weight