Antigen-Antibody Interactions and CDRs
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10 Terms
Where is antigen variability concentrated in antibodies?
Variable regions
What are hypervariable regions also called?
Complementarity-determining regions (CDRs)
How many CDRs are present per chain?
Three
How many total CDR loops form the binding site?
Six
What part of the antibody is most variable?
The antigen-binding site
What forces mediate antigen-antibody binding?
Non-covalent interactions
What types of epitopes can antibodies recognise?
Continuous or conformational
What determines antibody specificity?
CDR amino acid sequence `
What determines antibody affinity?
Strength of antigen-antibody interactions
How can antigen structure influence vaccine design?
By manipulating epitopes
Note 
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