Antigen-Antibody Interactions and CDRs

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10 Terms

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Where is antigen variability concentrated in antibodies?

Variable regions

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What are hypervariable regions also called?

Complementarity-determining regions (CDRs)

3
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How many CDRs are present per chain?

Three

4
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How many total CDR loops form the binding site?

Six

5
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What part of the antibody is most variable?

The antigen-binding site

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What forces mediate antigen-antibody binding?

Non-covalent interactions

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What types of epitopes can antibodies recognise?

Continuous or conformational

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What determines antibody specificity?

CDR amino acid sequence `

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What determines antibody affinity?

Strength of antigen-antibody interactions

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How can antigen structure influence vaccine design?

By manipulating epitopes