Biochem Lecture 1

Groups attached to the alpha carbon

Groups attached to the alpha carbon

Hydrogen, Amino Group (basic), Carboxyl Group (acidic), R-group/side chain

L or D more common in Amino Acids?

L config

CORN

Carbon, Oxygen, R group, Nitrogen —> L Config

Only Achiral Amino Acid

Glycine

Amino Acids with two chiral centers

Ile and Thr

Conditionally Charged Amino Acid

His

Amino Acid that Forms Disulfide Bridges

Cys

Amino Acid that doesn’t form H bonds

Pro

Nonpolar Amino Acids

Glycine, Alanine, Valine, Leucine, Isoleucine, Methionine, Phenylalanine, Tryptophan, Proline

Nonpolar Amino Acid Mnemonic

Grandma Always Visits London In May For Winston’s Party

Polar Amino Acids

Serine, Threonine, Cystine, Asparagine, Glutamine, Tyrosine

Polar Amino Acids Mnemonic

Santa’s Team Crafts New Quilts Yearly

Charged Amino Acids

Aspartic Acid, Glutamic Acid, Lysine, Arginine, Histidine

Charged Amino Acids Mnemonic

Dragons Eat Knights Riding Horses

Aromatic Amino Acids

Tryptophan, Tyrosine, Phenylalanine

pK of Carboxyl group

~2-3

pK of Amino Group

~9

Zwitterion

Has both pos and neg charged groups, usually net neutral

Isoelectric Point

pH at which net charge of molecule is Zero

Type of reaction to form Peptide Bonds

Condensation of OH from alpha-carboxyl to H from Amino group of adjacent AA.

Are peptide bonds generally cis or trans?

Trans