CP: Module 1.1: Chronic Pulmonary Pathophysiology - Other Obstructive Conditions

Irreversible dilation of airways due to destruction of airway walls.

What is bronchiectasis?

COPD,

cystic fibrosis,

tumors,

infections,

and idiopathic cases.

What are common causes of bronchiectasis?

Persistent productive cough, wheezing, and crackles.

What are signs of bronchiectasis?

Mutations in the CFTR gene affecting Na+/Cl− channels.

What causes cystic fibrosis?

Lungs, pancreas, liver, GI tract, sinuses, reproductive system.

What body systems are affected by CF?

Sweat chloride test at birth (>60 mmol/L).

How is CF usually diagnosed?

Lung infections.

What is the leading cause of death in CF?

Airway clearance, exercise, nutrition, and lung transplantation.

What treatments are important in CF?