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Self Sufficiency in growth signals
“Grow without go” (Oncogenes)
Insensitivity to antigrowth signals
“failure to stop” (Tumor suppressor genes ex: BRACA 1&2)
Evading apoptosis
“Broken self-destruct”
Sustained angiogenesis
“need to feed” (VEGF)
Tissue Invasion and Metastasis
“spread”