HD3Drugs2

Acyclovir

Nucleoside Analogues

Ganciclovir

Nucleoside Analogues

Foscarnet

Non-nucleoside Analogues

Oseltamivir

Neuraminidase Inh

Remdesivir

Nucleotide Analogue

Ribavirin

Nucleoside Analogues

Sofosbuvir

Nucleotide Polymerase Inh

Enfuvirtide

Blocks Fusion

Zidovudine (AZT)

NRTI

Abacavir (ABC)

NRTI

Tenofovir (TDF)

NRTI

Nevirapine (NVP)

NNRTI

Efavirenz (EFV)

NNRTI

Darunavir (DRV)

Protease Inh

Atazanovir (ATV)

Protease Inh

Ritonavir

Protease Inh

Dolutegravir

Integrase Inh

Metronidazole

Anaerobic Protozoa

Chloroquine

Apicomplexa Protozoa

Atovaquone

Apicomplexa Protozoa

Proguanil

Apicomplexa Protozoa

Artemether-Lumefantrine

Apicomplexa Protozoa

Artesunate

Apicomplexa Protozoa

Primaquine

Apicomplexa Protozoa

Sulfadiazine+Pyrimethane

Apicomplexa Protozoa

Sodium Stibogluconate

Kinetoplastid Protozoa

Nifurtimox-Eflornithine

Kinetoplastid Protozoa

Suramin

Kinetoplastid Protozoa

Melarsoprol

Kinetoplastid Protozoa

Mebendazole (MBZ)

Helminth

Pyrantel Pamoate

Helminth

Ivermectin

Helminth

Praziquantel

Helminth

Acyclovir

HSV-1, HSV-2, VZV, EBV

Ganciclovir

CMV (Cytomegalovirus)

Foscarnet

CMV (Cytomegalovirus), VZV

Oseltamivir

Influenza A, Influenza B

Remdesivir

Coronavirus

Ribavirin

Hep C, RSV

Sofosbuvir

Hep C

Enfuvirtide

HIV

Zidovudine (AZT)

HIV

Abacavir (ABC)

HIV

Tenofovir (TDF)

HIV, Hep B

Nevirapine (NVP)

HIV

Efavirenz (EFV)

HIV

Darunavir (DRV)

HIV

Atazanovir (ATV)

HIV

Ritonavir

HIV

Dolutegravir

HIV

Metronidazole

Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis

Chloroquine

P falciparum, P malariae, P ovale, P vivax

Atovaquone

P falciparum, P vivax

Proguanil

P falciparum, P vivax

Artemether-Lumefantrine

P falciparum

Artesunate

P falciparum

Primaquine

P ovale, P vivax

Sulfadiazine+Pyrimethane

Toxoplasma gondii

Sodium Stibogluconate

Leishmania

Nifurtimox-Eflornithine

Trypanosoma cruzi

Suramin

Trypanosoma cruzi

Melarsoprol

Trypanosoma cruzi

Mebendazole (MBZ)

Ascaris lumbricoides, Necator americanus, Enterobius vermicularis, Trichinella spiralis, Trichuris trichuria

Pyrantel Pamoate

Ascaris lumbricoides, Necator americanus, Enterobius vermicularis, Trichinella spiralis

Ivermectin

Strongyloides stercoralis

Praziquantel

Schistosoma mansoni, Taenia solium, Taenia saginata, Diphyllobothrium latum

Acyclovir

Guanine analogues (competitive inh of nucleic acid polymerases), only activated by viral protein thymidine kinase → triphosphate form inh viral DNA polymerase → chain term (irr)

Ganciclovir

Guanine analogues (competitive inh of nucleic acid polymerases), only activated by viral protein thymidine kinase → triphosphate form inh viral DNA polymerase → chain term (irr)

Foscarnet

direct inh of viral DNA pol, RNA pol, HIV RTase

Oseltamivir

inhibit viral neuraminidase

Remdesivir

inh RNA poly

Ribavirin

inh IMPDH (dec GTP) in DNA, induce mutations in RNA

Sofosbuvir

inh HCV NS5B RNA dep RNA poly, commonly combined with ledipasvir or ribavirin

Enfuvirtide

binds gp41 and blocks final stage of HIV fusion to CD4 cells

Zidovudine (AZT)

target viral RT with greater affinity than human DNA polymerases (chain termination)

Abacavir (ABC)

target viral RT with greater affinity than human DNA polymerases (chain termination)

Tenofovir (TDF)

target viral RT with greater affinity than human DNA polymerases (chain termination)

Nevirapine (NVP)

non comp of RT

Efavirenz (EFV)

non comp of RT

Darunavir (DRV)

lowers viral load, raises CD4s

Atazanovir (ATV)

lowers viral load, raises CD4s

Ritonavir

lowers viral load, raises CD4s

Dolutegravir

inh integrase

Metronidazole

free radicals damages DNA and proteins (prevents metabolism)

Chloroquine

reduction of heme metabolism, oxidative damage kills parasite

Atovaquone

selective mitochondrial inh

Proguanil

DHFR inh

Artemether-Lumefantrine

bind iron, cleave peroxide bridges, generates free radicals

Artesunate

bind iron, cleave peroxide bridges, generates free radicals

Primaquine

kills dormant in liver

Sulfadiazine+Pyrimethane

DHPS & DHFR inhibitors: blocks THFA production

Sodium Stibogluconate

interferes with antioxidant system

Nifurtimox-Eflornithine

metabolized to toxic free radicals/ornithine decarboxylase inh

Suramin

unknown

Melarsoprol

ornithine decarboxylase inh

Mebendazole (MBZ)

inh microtubule poly

Pyrantel Pamoate

depolarizing NM blocking agent (spastic paralysis)

Ivermectin

kills larvae, paralysis via glu-gated cl- channels (only invertebrates)

Praziquantel

spastic paralysis and tegument damage

Acyclovir

HSV > VZV >> EBV; no activity against CMV