Normocytic Anemias and Related Disorders

These flashcards cover key terms and concepts related to normocytic anemias, their causes, classifications, and related hematological conditions.

EPO deficiency

The cause of anemia associated with renal failure.

Myelophthisic anemia

Anemia caused by invasion of bone marrow by cancer cells or fibrous tissue.

Aplastic anemia

A disorder of hematopoietic stem cells characterized by the failure to produce blood cells.

Fanconi's Anemia

The most common hereditary form of aplastic anemia, leading to inherited pancytopenia.

Glucose-6-phosphate dehydrogenase deficiency

A sex-linked recessive condition that affects RBCs' ability to protect against oxidative damage.

Heinz Bodies

Aggregates of denatured hemoglobin resulting from oxidative injury to red blood cells.

Sickle cell disease

A genetic disorder characterized by the production of abnormal hemoglobin, leading to sickle-shaped RBCs.

Immunologic changes

A possible pathogenesis of aplastic anemia linked to autoimmune processes.

Hemoglobinopathy

Hereditary defects in the production of hemoglobin, resulting in anemia.

Reticulocytosis

An increase in reticulocytes, indicating an active response to anemia.

Direct Antiglobulin Test (DAT)

A laboratory test used to detect immune-mediated hemolytic anemia.

Painless lymphadenopathy

The clinical hallmark of lymphoma.

Clonal Hematopoiesis

The expansion of a single clone of stem cells in the bone marrow.

Myelogenous leukemia

A type of leukemia characterized by the proliferation of myeloid cells.

Normocytic anemias

Anemias characterized by normal red blood cell size.

Spherocytosis

A condition characterized by spherically shaped red blood cells.

Autologous transfusion

A procedure where patients donate their own blood for future use.

Anisocytosis

Variation in the size of red blood cells, often seen in blood smear.

Reticulocyte index

A measure of the number of reticulocytes in the blood to assess bone marrow function.