Reactive proliferation benign and infection

generation of t cell receptors

• TCR gene is split then recombined

• receptor has two chains

• if chains cannot interact or receptor recognises self then it is eliminated

what binds to major histocompatability molecules MHC

• intracellular proteins broken down and bind to groove of MHC

• non self proteins displayed on t cells can also bind

how d cytotoxic t cells degrade intracellular proteins

• receive antigens from lymph node

• bind to form specific bond

• apoptosis

perforin

• small pores to form in target cell

• granzyme and granulysin enter cell

• stimulate apoptosis

FAS

• binds to fas ligand

• sets up signals to induce apoptosis

what is simplest antibody form

IgF

antibody selection

• in lymph node

• hypermutated antibodies undergo selection

• higher affinity antibodies become more dominant

opinisation

• antigen is coated in opsins

• allows destruction from monocytes and macrophages

rheumatoid disease

• uncontrolled immune response against joints

• autoantibodies

• immune suppressive treatments reduce severity of reactions