chapter 32 - myeloproliferative neoplasms

CML

peripheral blood film

• increased neutrophils with left shift

• basophils

• eosinophils

• platelets

this is highly suggestive of?

t(9;22)

chromosome abnormality associated with CML

FISH positive for BCR::ABL1 fusion

px

• WBC count — 30 × 10⁹/L

• WBC differential

  • segmented neutrophils — 38%

  • bands — 17%

  • metamyelocytes — 7%

  • myelocytes — 20%

  • promyelocytes — 10%

  • eosinophils — 3%

  • basophils — 5%

which of the following test results would be helpful in determining whether the px has CML?

transformation to acute leukemia

px whose CML has been previously diagnosed has circulating blasts & promyelocytes that total 30% of leukocytes?

this disease is considered to be in what phase?

JAK2 V617F

most common mutation found in px with primary polycythemia vera

erythrocytosis with thrombocytosis, and granulocytosis most of the time

peripheral blood in polycythemia vera typically manifests

essential thrombocytopenia

px

• platelet count — 700 × 10⁹/L

  • abnormalities in size, shape, & granularity of platelets

• WBC count — 12 × 10⁹/L

• Hgb — 11 g/dL

• Philadelphia chromosome is not present

what is the most likely diagnosis?

infections

complications of essential thrombocytopenia include all except

• thrombosis

• hemorrhage

• seizures

• infections

teardrop-shaped erythrocytes

NRBCs

immature granulocytes

pattern that is characteristic of peripheral blood in px with primary myelofibrosis

pancytopenia

bone marrow fibrosis associated with PMF results in