drug

Olsalazine

Prodrug for ulcerative colitis comsist of 2 mesalamine

Chloramphenicol) palmitate

Prodrug to mask the bitterness of chloramphenicol

Prodrug

compounds that are inactive in their native form but are easily metabolized to the active agent.

Enalapril

ethyl ester of enalaprilic acid, ACE Inhibitor much more readily absorbed orally

Advantage of paranteral administration

Rapid effect in emergency in case we can't take drug orally bypass 1 metabolism

BBB

membranes of tightly joined epithelial cells lining the cerebral capillaries which protects the brain from exposure to a large number of metabolites and chemicals)

Methylprednisolone

active form

is slightly water-insoluble

found in tablets.

Methylprednisolone acetate

Essentially, water insoluble

Acetate ester

Found in tropical ointment and sterile Aquas suspension for intramuscular injection

Hydrolysed, to active form by esterase

Methylprednisolone sodium succinate

water-soluble

sodium salt of succinate ester

Found an oral intravenous, intra, muscular

Hydrolzed to, active form by estrase

Retonoic acid

Treat psoriasis

Etretinate

Used to treat cirrhosis, it has long half life, 120 days six month treatment make teratogenic effect

Acitretin

It's it's an active metabolite, not a pro drug has shorter, half-life and higher washing out. The half-life is 33-96, hour you when the woman is planning to become a pregnant but also teratogenic effect

Suami stays three months it's good or bad

Firstly, it may seem as advantage, but if this, but if the patient have serious adverse reaction, a significant time is needed for the concentration to fall below toxic levels

Depot

Is the body area in which substance can accumulate stored or depost

First pass metabolism

A portion of a drug will be transported to a liver, which will be converted to inactive metabolite by hepatic enzyme trip to the liver

Lidocaine

Have first past effect because over 60 of the drug will go to the first pass metabolism, so administrated orally will not be effective, so we give it intravenously for cardiac academia and in administration we administrate too much quantities were toxic responses sent to degrees, because of the rapid bio transformation to inactive metapolite

Tocinidine

Is a primary amine analog of lidocaine half life 15 h

Sulindac

Prodrug being reduced to active sulfide metabolite

Azatheoprine

Immuno suppressant prodrug is being claves to purine metabolite 6 mercaptopurine

Acyclovir

Purine and pyrimidine antimetabolite and anti-viral agent prodrug is converted to nucleotide form acyclovir triphosphate

No formation of drug receptors complex

Higher and more frequent doses may be administrated

fexofenadine

Second generation of antihistamine less sedation effect, because less penetration to CNS

Tamoxifen

Oestrogen antagonist in mammary glands but it's a agonist in bone and uterus

raloxifene

Don't have much agonist property on uterus , but it's antagonist in breast and agonist in bone