Components of Complement Proteins
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17 Terms
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C1q
binds to Fc portion of IgM and IgG molecules
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C1r
activates C1s
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C1s
cleaves C4 and C2
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C4
part of C3 convertase
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C2
binds to C4b to form C3 convertase
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C3
central pivot point and key intermediate of all pathways
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C5
initiates membrane attack complex (MAC)
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C6
bind to C5b in MAC
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C7
binds to C5b6 in MAC
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C8
starts pore formation in membrane
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C9
polymerizes to cause cell lysis
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Factor B
binds C3b to form C3 convertase
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Factor D
cleaves factor B
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Properdin
stabilizes the C3bBb complex
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MBL
binds to mannose; homologous to C1q; mannose binding lectin
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MASP 1
similar to C1r; MBL associated serine protease 1
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MASP 2
similar to C1s; splits C4 & C2; MBL associated serine protease 2
Note 
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