protein based therapeutics (luke) - 1151

*have to add examples

proteins

made of amino acids > that can be polar/nonpolar/aromatic/acidic/neutral etc.

many amino acids have chiral centers > they will exist in one enantiomer only

amino acids

amino group on one end

carboxylic acid on the other end

carbon attached to amino group also has a variable side chain (R)

properties: (as they get deprotonated/protonated in body environment) water soluble, high MP and can form crystals (good crystallinity)

proteins as therapeutics (enzymatic/regulatory)

replace a deficient or abnormal protein > that does not function correctly

NOT orally available, must be injected (or other form of delivery)

proteins as therapeutics (antibodies for targeting)

antibodies are large protein complexes > their function is surrounding foreign bodies and trigger t-cell response (engulf and destroy)

THERAPEUTIC APPS: deliberately generate antibodies to bind to a particular protein/receptor on target cells (so t-cells will destroy target OR function may just be inactivated)

proteins as therapeutics (vaccines)

PREVIOUS METHODS

> destroy/mash the virus and inject that

> mutate virus into weak form

DEVELOPED METHODS

> specific proteins are synthesized and purified (faster)