Laboratory Findings in Fragmentation vs Macrophage-mediated Hemolysis
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FlashcardsHemolytic anemia (Acute, Fragmentation)
Hgb level: Rapidly dropping
Indirect Bilirubin: Delayed
Reticulocytosis: Delayed
Sphero/Schisto: Schistocytes
Hemolytic anemia (Acute, Macrophage-mediated)
Hgb level: Rapidly dropping
Indirect Bilirubin: Delayed
Reticulocytosis: Delayed
Sphero/Schisto: Spherocytes
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Hemolytic anemia (Acute, Fragmentation)
Hgb level: Rapidly dropping
Indirect Bilirubin: Delayed
Reticulocytosis: Delayed
Sphero/Schisto: Schistocytes
Hemolytic anemia (Acute, Macrophage-mediated)
Hgb level: Rapidly dropping
Indirect Bilirubin: Delayed
Reticulocytosis: Delayed
Sphero/Schisto: Spherocytes
Hemolytic anemia (Chronic, Fragmentation)
Hgb level: Persistently low
Indirect Bilirubin: Persistent
Reticulocytosis: Persistent
Sphero/Schisto: Schistocytes
Hemolytic anemia (Chronic, Macrophage-mediated)
Hgb level: Persistently low
Indirect Bilirubin: Persistent
Reticulocytosis: Persistent
Sphero/Schisto: Spherocytes
Acute Hemorrhage
Hgb level: Rapidly dropping
Indirect Bilirubin: Absent
Reticulocytosis: Delayed
Sphero/Schisto: Absent
Hemodilution
Hgb level: Rapidly dropping
Indirect Bilirubin: Absent
Reticulocytosis: Absent
Sphero/Schisto: Absent
Recovery from hemorrhage
Hgb level: Rising
Indirect Bilirubin: Absent
Reticulocytosis: Present
Sphero/Schisto: Absent
Treated anemia (iron, Vitamin B12, or folate deficiency)
Hgb level: Rising
Indirect Bilirubin: Absent / Declining
Reticulocytosis: Present
Sphero/Schisto: Absent
Hemorrhage into a body cavity
Hgb level: Rapidly dropping
Indirect Bilirubin: Delayed
Reticulocytosis: Delayed
Sphero/Schisto: Absent
Ineffective erythropoiesis (e.g. megaloblastic anemia)
Hgb level: Dropping
Indirect Bilirubin: Persistent
Reticulocytosis: Absent
Sphero/Schisto: Absent
Note 
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