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Cell Division
Process in which a cell divides into two new daughter cells
Asexual reproduction
Process of reproduction involving a single parent that results in offspring that are genetically identical to the parent
Sexual reproduction
Type of reproduction in which cells from two parents unite to form the first cell of a new organism
Chromosome
Threadlike structure within the nucleus that contains genetic information that is passed on from one generation to the next
Chromatin
Substance found in eukaryotic chromosomes that consists of DNA tightly coiled around histones
Cell Cycle
Series of events in which a cell grows, prepares for division, and divides to form two daughter cells
Interphase
Period of the cell cycle between cell divisions in which the cell grows
Mitosis
Part of eukaryotic cell division during which the cell nucleus divides
Cytokinesis
Division of the cytoplasm to form two separate daughter cells
Prophase
First and longest phase of mitosis in which the genetic material inside the nucleus condenses and the chromosomes become visible
Centromere
Region of a chromosome where the two sister chromatids attach
Chromatid
One of two identical 'sister' parts of a duplicated chromosome
Centriole
Structure in an animal cell that helps to organize cell division
Metaphase
Phase of mitosis in which the chromosomes line up across the center of the cell
Anaphase
Phase of mitosis in which the chromosomes separate and move to opposite ends of the cell
Telophase
Phase of mitosis in which the distinct individual chromosomes begin to spread out into a tangle of chromatin
Cyclin
One of a family of proteins that regulates the cell cycle in eukaryotic cells
Growth factor
One of a group of external regulatory proteins that stimulate the growth and division of cells
Apoptosis
The process of programmed cell death
Cancer
Disorder in which some of the body's cells lose the ability to control growth
Tumor
Mass of rapidly dividing cells that can damage surrounding tissue
Embryo
Developing stage of a multicellular organism
Differentiation
Process in which cells become specialized in structure and function
Totipotent
Cells that are able to develop into any type of cell found in the body (including cells that make up the extraembryonic membranes and placenta)
Blastocyst
Stage of early development in mammals that consists of a hollow ball of cells
Pluripotent
Cells that are capable of developing into most, but not all, of the body's cell types
Stem cell
Unspecialized cell that can give rise to one or more types of specialized cells
Multipotent
Cell with limited potential to develop into many types of differentiated cells
Genetics
Scientific study of heredity
Fertilization
Process in sexual reproduction in which male and female reproductive cells join to form a new cell
Trait
Specific characteristic of an individual
Hybrid
Offspring of crosses between parents with different traits
Gene
Sequence of DNA that codes for a protein and thus determines a trait; factor that is passed from parent to offspring
Allele
One of a number of different forms of a gene
Principle of dominance
Mendel's second conclusion, which states that some alleles are dominant, and others are recessive
Segregation
Separation of alleles during gamete formation
Gamete
A sex cell
Probability
Likelihood that a particular event will occur
Homozygous
Having two identical alleles for a particular gene
Heterozygous
Having two different alleles for a particular gene
Phenotype
Physical characteristics of an organism
Genotype
Genetic makeup of an organism
Punnett square
Diagram that can be used to predict the genotype and phenotype combinations of a genetic cross
Independent assortment
One of Mendel's principles that states that genes for different traits can segregate independently during the formation of gametes
Incomplete dominance
Situation in which one allele is not completely dominant over another allele
Codominance
Situation in which the phenotypes produced by both alleles are completely expressed
Multiple allele
A gene that has more than two alleles
Polygenic trait
Trait controlled by two or more genes
Homologous
Term used to refer to chromosomes in which one set comes from the male parent and one set comes from the female parent
Diploid
Term used to refer to a cell that contains two sets of homologous chromosomes
Haploid
Term used to refer to a cell that contains only a single set of genes
Meiosis
Process in which the number of chromosomes per cell is cut in half through the separation of homologous chromosomes in a diploid cell
Tetrad
Structure containing four chromatids that forms during meiosis
Crossing-over
Process in which homologous chromosomes exchange portions of their chromatids during meiosis
Zygote
A fertilized egg
Transformation
Process in which one strain of bacteria is changed by a gene or genes from another strain of bacteria
Bacteriophage
Kind of virus that infects bacteria
Base Pairing
Principle that bonds in DNA can form only between adenine and thymine and between guanine and cytosine
Replication
Process of copying DNA prior to cell division
DNA Polymerase
Principle enzyme involved in DNA replication
Telomere
Repetitive DNA at the end of a eukaryotic chromosome
RNA
Single-stranded nucleic acid that contains the sugar ribose
Messenger RNA
Type of RNA that carries copies of instructions for the assembly of amino acids into proteins from DNA to the rest of the cell
Ribosomal RNA
Type of RNA that combines with proteins to form ribosomes
Transfer RNA
Type of RNA that carries each amino acid to a ribosome during protein synthesis
Transcription
Synthesis of an RNA molecule from a DNA template
RNA polymerase
Enzyme that links together the growing chain of RNA nucleotides during transcription using a DNA strand as a template
Promoter
Specific region of a gene where RNA polymerase can bind and begin transcription
Intron
Sequence of DNA that is not involved in coding for a protein
Exon
Expressed sequence of DNA; codes for a protein
Polypeptide
Long chain of amino acids that makes proteins
Genetic code
Collection of codons of mRNA, each of which directs the incorporation of a particular amino acid into a protein during protein synthesis
Codon
Group of three nucleotide bases in mRNA that specify a particular amino acid to be incorporated onto a protein
Translation
Process by which the sequence of bases of an mRNA is converted into the sequence of amino acids of a protein
Anticodon
Group of three bases on a tRNA molecule that are complementary to the three bases of a codon of mRNA
Gene expression
Process by which a gene produces its product and the product carries out its function
Mutation
Change in the genetic material of a cell
Point mutation
Gene mutation in which a single base pair in DNA has been changed
Frameshift mutation
Mutation that shifts the 'reading frame' of the genetic message by inserting or deleting a nucleotide
Mutagen
Chemical or physical agents in the environment that interact with DNA and may cause a mutation
Polyploidy
Condition in which an organism has extra sets of chromosomes
Operon
In prokaryotes, a group of adjacent genes that shares a common operator and promoter and are transcribed into a single mRNA
Operator
Short DNA region, adjacent to the promoter of a prokaryotic operon, that binds repressor proteins responsible for controlling the rate of transcription of the operon
RNA Interference
Introduction of double-stranded RNA into a cell to inhibit gene expression
Homeotic gene
A class of regulatory genes that determine the identity of body parts and regions in an animal embryo
Homeotic gene
A class of regulatory genes that determine the identity of body parts and regions in an animal embryo. Mutations in these genes can transform one body part into another.
Homeobox gene
genes that code for transcription factors that activate other genes that are important in cell development and differentiation
Hox gene
a group of homeotic genes clustered together that determine the head to tail identity of body parts in animals. All hox genes contain the homeobox DNA sequence.
Genome
Entire set of genetic information that an organism carries in its DNA
Karyotype
Micrograph of the complete diploid set of chromosomes grouped together in pairs, arranged in order of decreasing size
Sex chromosome
One of two chromosomes that determines an individual's sex
Autosome
Chromosome that is not a sex chromosome; also called autosomal chromosome
Sex-linked gene
A gene located on a sex chromosome
Pedigree
Chart that shows the presence or absence of a trait according to the relationships within a family across several generations
Nondisjunction
Error in meiosis in which the homologous chromosomes fail to separate properly
Restriction enzyme
Enzyme that cuts DNA at a sequence of nucleotides
Gel electrophoresis
Procedure used to separate and analyze DNA fragments by placing a mixture of DNA fragments at one end of a porous gel and applying an electrical voltage to the gel
Bioinformatics
Application of mathematics and computer science to store, retrieve, and analyze biological data
Genomics
Study of whole genomes, including genes and their functions
Selective breeding
Method of breeding that allows only those organisms with desired characteristics to produce the next generation