Intro to Neuropharm Cocaine and Amphetamines

Blocks reuptake of DA, NE, and 5-HT

What is cocaine’s mechanism of action?

Amphetamines and Methamphetamines

Synthetic drug structurally related to DA

amphetamine

indirect catecholamine agonist

amphetamine

Stimulate DA and NE release and block reuptake

Enters nerve terminal by DAT and stimulates release of DA from vesicles; and alters DAT to act in the reverse direction to release DA into the synapse

What are the two ways amphetamines stimulates massive DA release?

Amphetamines

Cause heightened alertness, increased confidence, feelings of exhilaration, reduced fatigue, and generalized sense of well-being. Reduced sleep-time, especially REM sleep, can enhance athletic performance

Amphetamine

What is the base of Adderall?

Adderall

What is a drug treatment for ADHD?

Schizophrenia

Repeated methamphetamine use can lead to a psychotic state that is similar to?