DNA Repair and Recombination

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5 Terms

1
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What are common sources of DNA damage?

Replication errors, chemical mutagens, and radiation.

2
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What are the three major DNA repair systems?

Base excision repair (BER), nonhomologous end joining (NHEJ), and homologous recombination (HR).

3
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Which repair system is error-prone and why?

NHEJ, because it joins DNA ends without a template.

4
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Which repair system is mostly error-free?

Homologous recombination, because it uses a template strand.

5
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What is the link between DNA repair defects and cancer?

Impaired repair allows mutations to accumulate, promoting cancer development.