Salmonella

Enteric/Typhoid Fever is caused by

S. typhi or

S. paratyphi

Typhoid fever is characterized by

Step-ladder fever

Abdominal rose spots

Hepatosplenomegaly

Typhoid fever incubation period

10-14 days

Non-typhoid salmonella causes

Enterocolitis → less severe, self-limited

Non-typhoidal Salmonella species

Which is the most common?

S. enteritidis (most common)

S. tyhpimurium

Salmonella invades which cells?

M cells

Peyer’s patches

Survives in Macrophages (typhoidal)

Salmonella selective media

SS agar

Hektoen

XLD

Bismuth sulfate

Salmonella treatment for Enterocolitis

Supportive: Fluids, electrolytes

Antibiotics NOT recommended → may prolong carriage

Salmonella treatment for Typhoid fever

Uncomplicated: Oral Azithromycin

Severe/Complicated: Ceftriaxone, Fluoroquinolones

3% of Typhoid survivors are carriers in what organ

Chronic Gallbladder Carriage

Salmonella vaccines

Oral live attenuated Ty21a

Injectable Vi polysaccharide vaccine (ViCPS)