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Lecture 34: Regulation of Digestion
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Cephalic Regulation
\-Control of digestion via head
\-Stimulation of saliva secretion (No hormonal Control)
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Parasympathetic nervous system (Cephalic)
\-acetylcholine
\-Promotes secretion of water saliva and enzymes for digestion
\-We think of food
\-Ingested food stimulates chemoreceptors or mechanoreceptors
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Sympathetic stimulation (cephalic)
\-Norepinephrine
\-Promotes mucus release to prevent drying of mouth during increased respiration
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Stimulation of Cephalic Regulation lead to
stimulation of other GI secretions and smooth muscle motility in the stomach, small intestine, pancreas, liver, gallbladder
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Stomach
\-Hormone: Gastrin
\-Chemical stim. Peptides amino acids pH > 2
\-Target: stomach
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Intestine
\-Hormone: Gastrin
\-Chemical stim. Peptides amino acids pH > 2
\-Target: stomach
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Intestine
Hormone: Secretin
\-Chem Stim: Low pH
\-Target: Pancreas (exocrine), stomach
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Intestine
\-Hormone: Cholecytokinin
\-Chem Stim: Fatty acids, amino acids
\-Target: Gallbladder, pancreas (endocrine), Stomach
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Intestine
Hormone: Gastric Inhibitory peptide, Glucose-dependent insulinotropic peptide
\-Chem Stim: Glucose, Fatty acids, Amino acids
\-Target: Pancreas (endocrine), stomach
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Intestine
Hormone: Glucagon-like peptide-1
\-Chem Stim: Mixed meal carbs or fats
\-Target: Pancreas (endocrine)